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C-terminal neuropep...
C-terminal neuropeptide Y fragments are mast cell-dependent vasodepressor agents
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- Shen, G H (författare)
- Georgetown University
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- Grundemar, L (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Zukowska-Grojec, Z (författare)
- Georgetown University
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- Håkanson, R (författare)
- Cornell University
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- Wahlestedt, C (författare)
- Cornell University
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(creator_code:org_t)
- Elsevier BV, 1991
- 1991
- Engelska.
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Ingår i: European Journal of Pharmacology. - : Elsevier BV. - 0014-2999. ; 204:3, s. 249-256
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Neuropeptide Y (NPY) is a well-established vasopressor agent present in sympathetic perivascular nerves. Recently, it was found that high doses of the peptide cause a biphasic pressor-depressor response upon intravenous administration. We now report that C-terminal NPY fragments (NPY-(18-36) and NPY-(22-36] given intravenously to conscious or pithed (areflexive) male Sprague-Dawley rats mimic the depressor component of the NPY-(1-36) response while displaying very low pressor activity. Additionally, we have found that the depressor component is blocked by the histamine H1-antagonist, mepyramine. Since the fragment, NPY-(22-36), was equipotent with NPY in inducing histamine release from isolated peritoneal mast cells, we conclude that short C-terminal NPY fragments, like NPY itself, act on mast cells to initiate histamine-mediated cardiovascular actions. Such actions may conceivably be accounted for by the abundance of positively charged amino acid residues in the C-terminus. Moreover, these fragments have little affinity for vascular NPY receptors, as indicated by their poor ability to displace iodinated NPY or peptide YY (PYY) from specific binding sites on vascular smooth muscle cells derived from rat aorta. In conclusion, we propose that short C-terminal NPY fragments, which contain several positively charged amino acid residues, retain the ability of NPY to release histamine from rat mast cells while being essentially devoid of direct vascular motor activity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Animals
- Aorta/metabolism
- Binding, Competitive
- Blood Pressure/drug effects
- Cells, Cultured
- Consciousness
- Decerebrate State
- Heart Rate/drug effects
- Histamine Release/drug effects
- Kinetics
- Male
- Mast Cells/drug effects
- Muscle, Smooth, Vascular/metabolism
- Neuropeptide Y/metabolism
- Peptide Fragments/pharmacology
- Peptide YY
- Peptides/pharmacology
- Pyrilamine/pharmacology
- Rats
- Rats, Inbred Strains
- Receptors, Neuropeptide Y
- Receptors, Neurotransmitter/drug effects
- Structure-Activity Relationship
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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