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The estimated effec...
The estimated effect of season and vitamin D in the first trimester on pubertal timing in girls and boys : A cohort study and an instrumental variable analysis
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- Gaml-Sørensen, Anne (författare)
- University of California, Los Angeles,Aarhus University
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- Brix, Nis (författare)
- Aarhus University,Aarhus University Hospital
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- Ernst, Andreas (författare)
- Aarhus University,Aarhus University Hospital
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- Lunddorf, Lea Lykke Harrits (författare)
- Aarhus University
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- Lindh, Christian (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Toft, Gunnar (författare)
- Aarhus University Hospital
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- Henriksen, Tine Brink (författare)
- Aarhus University Hospital
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- Arah, Onyebuchi A. (författare)
- Aarhus University,University of California, Los Angeles
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- Ramlau-Hansen, Cecilia Høst (författare)
- University of California, Los Angeles,Aarhus University
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(creator_code:org_t)
- 2023
- 2023
- Engelska 13 s.
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Ingår i: International Journal of Epidemiology. - 0300-5771. ; 52:5, s. 1328-1340
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Season of birth has been associated with age at menarche. Maternal vitamin D levels in pregnancy may explain this effect. We investigated whether the season of first trimester or maternal 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with pubertal timing in children. Methods: We conducted a follow-up study of 15 819 children born in 2000-03 from the Puberty Cohort, nested in the Danish National Birth Cohort (DNBC). Mean differences in attaining numerous pubertal markers, including a combined estimate for the average age at attaining all pubertal markers, were estimated for low (November-April) relative to high (May-October) sunshine exposure season in the first trimester using multivariable interval-censored regression models. Moreover, we conducted a two-sample instrumental variable analysis using season as an instrument for maternal first-Trimester 25(OH)D3 plasma levels obtained from a non-overlapping subset (n = 827) in the DNBC. Results: For the combined estimate, girls and boys of mothers who had their first trimester during November-April had earlier pubertal timing than girls and boys of mothers whose first trimester occurred during May-October:-1.0 months (95% CI:-1.7 to-0.3) and-0.7 months (95% CI:-1.4 to-0.1), respectively. In the instrumental variable analysis, girls and boys also had earlier pubertal timing: respectively,-1.3 months (95% CI:-2.1 to-0.4) and-1.0 months (95% CI:-1.8 to-0.2) per SD (22 nmol/L) decrease in 25(OH)D3. Conclusions: Both first pregnancy trimester during November-April and lower 25(OH)D3 were associated with earlier pubertal timing in girls and boys.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- 25-hydroxyvitamin D
- delayed effects
- fetal programming
- instrumental variable analysis
- maternal exposure
- pregnancy season
- prenatal exposure
- pubertal development
- Seasonal effect
- vitamin D
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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