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Decreased Splenic C...
Decreased Splenic CD4(+) T-Lymphocytes in Apolipoprotein M Gene Deficient Mice
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Wang, Zhigang (författare)
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Luo, Guanghua (författare)
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Feng, Yuehua (författare)
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Zheng, Lu (författare)
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Liu, Hongyao (författare)
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Liang, Yun (författare)
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Liu, Zhonghua (författare)
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Shao, Peng (författare)
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- Berggren Söderlund, Maria (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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Zhang, Xiaoying (författare)
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- Xu, Ning (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- Hindawi Limited, 2015
- 2015
- Engelska.
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Ingår i: BioMed Research International. - : Hindawi Limited. - 2314-6133 .- 2314-6141.
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Spleen T-lymphocytes, especially CD4(+) T-cells, have been demonstrated to be involved in broad immunomodulation and host-defense activity in vivo. Apolipoprotein M gene (apoM) may have an important role in the regulation of immunoprocess and inflammation, which could be hypothesized to the apoM containing sphingosine-1-phosphate (S1P). In the present study we demonstrate that the splenic CD4(+) T-lymphocytes were obviously decreased in the apoM gene deficient (apoM(-/-)) mice compared to the wild type (apoM(+/+)). Moreover, these mice were treated with lipopolysaccharide (LPS) and it was found that even more pronounced decreasing CD4(+) T-lymphocytes occurred in the spleen compared to the apoM(+/+) mice. The similar phenomena were found in the ratio of CD4(+)/CD8(+) T-lymphocytes. After administration of LPS, the hepatic mRNA levels of tumor necrosis factor-alpha (TNF-alpha) and monocyte chemotactic protein-1 (MCP-1) were markedly increased; however, there were no statistical differences observed between apoM(+/+) mice and apoM(-/-) mice. The present study demonstrated that apoM might facilitate the maintenance of CD4(+) T-lymphocytes or could modify the T-lymphocytes subgroups in murine spleen, which may further explore the importance of apoM in the regulation of the host immunomodulation, although the detailed mechanism needs continuing investigation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- art (ämneskategori)
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Till lärosätets databas
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Wang, Zhigang
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Luo, Guanghua
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Feng, Yuehua
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Zheng, Lu
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Liu, Hongyao
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Liang, Yun
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visa fler...
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Liu, Zhonghua
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Shao, Peng
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Berggren Söderlu ...
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Zhang, Xiaoying
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Xu, Ning
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Lunds universitet