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Simultaneous mappin...
Simultaneous mapping of T1and B1+ in human brain at 7T
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- Olsson, Hampus (författare)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Andersen, Mads (författare)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Faculty of Medicine,Philips Healthcare, Denmark
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- Kadhim, Mustafa (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Helms, Gunther (författare)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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(creator_code:org_t)
- 2022-01-17
- 2022
- Engelska.
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Ingår i: Magnetic Resonance in Medicine. - : Wiley. - 1522-2594 .- 0740-3194. ; 87:6, s. 2637-2649
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PurposeTo map T1 and the local flip angle (B1+) in human brain using a single MP3RAGE sequence with 3 rapid acquisitions of gradient echoes (RAGEs).Theory and methodsA third RAGE with a relatively high flip angle was appended to an MP2RAGE sequence. Through curve fitting and a rational approximation for small flip angles and short TR, closed form solutions for T1 and B1+ were derived. The influence of different k-space encoding schemes on precision and whether edge enhancement artifacts could be reduced with a saturation pulse applied prior to the third RAGE were explored. Validation of T1 estimates was performed using single-slice inversion recovery (IR) and a subsequent region-of-interest–based comparison, whereas validation of B1+ was performed using a whole brain pixelwise comparison to a DREAM flip angle mapping protocol. Lastly, MP3RAGE was compared to T1-mapping by MP2RAGE with separate B1+ correction.ResultsWhole brain maps of T1 and B1+ at 1 mm isotropic resolution were obtained with MP3RAGE in 06:37 min. A linear–reverse centric–reverse centric phase-encoding order of the 3 RAGEs improved precision, and artifacts were successfully reduced with the saturation pulse. Estimations of T1 and B1+ deviated +2.5 ± 3.1% and −1.7 ± 8.6% from their respective references.ConclusionT1 and B1+ can be mapped simultaneously using MP3RAGE. The approach can be thought of as combining MP2RAGE with a dual flip angle T1-mapping protocol. Both maps can be solved for analytically and will be inherently co-registered at the high resolution associated with MPRAGE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- 7T, B1+ mapping, dual flip angle, MPRAGE, T1- mapping
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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