Sökning: onr:"swepub:oai:lup.lub.lu.se:6bcbf607-ae3a-45ea-b9af-336a3f7bc45a" > Genetic Predictors ...
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000 | 04847naa a2200565 4500 | |
001 | oai:lup.lub.lu.se:6bcbf607-ae3a-45ea-b9af-336a3f7bc45a | |
003 | SwePub | |
008 | 230120s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/6bcbf607-ae3a-45ea-b9af-336a3f7bc45a2 URI |
024 | 7 | a https://doi.org/10.2337/db21-07412 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a McCaffery, Jeanne M.u University of Connecticut4 aut |
245 | 1 0 | a Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention : The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention |
264 | c 2022-01-18 | |
264 | 1 | b American Diabetes Association,c 2022 |
300 | a 8 s. | |
520 | a Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI (WCadjBMI and WHRadjBMI), but it remains unclear whether these SNPs relate to change in WCadjBMI or WHRadjBMI with lifestyle intervention for weight loss. We hypothesized that polygenic scores (PS) comprised of 59 SNPs previously associated with central adiposity would predict less of a reduction in WCadjBMI or WHRadjBMI at 8-10 weeks in two lifestyle intervention trials, NUGENOB and DiOGenes, and at 1 year in five lifestyle intervention trials, Look AHEAD, Diabetes Prevention Program, Diabetes Prevention Study, DIETFITS, and PREDIMED-Plus. One-SD higher PS related to a smaller 1-year change in WCadjBMI in the lifestyle intervention arms at year 1 and thus predicted poorer response (β = 0.007; SE = 0.003; P = 0.03) among White participants overall and in White men (β = 0.01; SE = 0.004; P = 0.01). At average weight loss, this amounted to 0.20-0.28 cm per SD. No significant findings emerged in White women or African American men for the 8-10-week outcomes or for WHRadjBMI. Findings were heterogeneous in African American women. These results indicate that polygenic risk estimated from these 59 SNPs relates to change in WCadjBMI with lifestyle intervention, but the effects are small and not of sufficient magnitude to be clinically significant. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Jablonski, Kathleen A.u George Washington University4 aut |
700 | 1 | a Pan, Qingu George Washington University4 aut |
700 | 1 | a Astrup, Arneu Novo Nordisk Foundation4 aut |
700 | 1 | a Revsbech Christiansen, Maleneu University of Copenhagen4 aut |
700 | 1 | a Corella, Doloresu University of Valencia4 aut |
700 | 1 | a Corso, Lauren M.L.u University of Connecticut4 aut |
700 | 1 | a Florez, Jose C.u Broad Institute,Massachusetts General Hospital,Harvard Medical School4 aut |
700 | 1 | a Franks, Paul W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Gardner, Christopheru Stanford University School of Medicine4 aut |
700 | 1 | a Hansen, Torbenu University of Copenhagen4 aut |
700 | 1 | a Kilpeläinen, Tuomas O.u University of Copenhagen4 aut |
700 | 1 | a Knowler, William C.u National Institute of Diabetes and Digestive and Kidney Diseases4 aut |
700 | 1 | a Lindström, Jaanau Finnish National Institute for Health and Welfare4 aut |
700 | 1 | a Saris, Wim H.M.u Maastricht University4 aut |
700 | 1 | a Sørensen, Thorkild I.A.u University of Copenhagen4 aut |
700 | 1 | a Tuomilehto, Jaakkou University of Helsinki,Finnish National Institute for Health and Welfare,King Abdulaziz University4 aut |
700 | 1 | a Uusitupa, Mattiu University of Eastern Finland4 aut |
700 | 1 | a Wing, Rena R.u Brown University4 aut |
700 | 1 | a Agurs-Collins, Tanyau National Cancer Institute, USA4 aut |
710 | 2 | a University of Connecticutb George Washington University4 org |
773 | 0 | t Diabetesd : American Diabetes Associationg 71:4, s. 669-676q 71:4<669-676x 1939-327Xx 0012-1797 |
856 | 4 | u http://dx.doi.org/10.2337/db21-0741y FULLTEXT |
856 | 4 | u https://doi.org/10.2337/figshare.17890715 |
856 | 4 8 | u https://lup.lub.lu.se/record/6bcbf607-ae3a-45ea-b9af-336a3f7bc45a |
856 | 4 8 | u https://doi.org/10.2337/db21-0741 |
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