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Arterial Blood Pres...
Arterial Blood Pressure Induces Transient C4b-Binding Protein in Human Saphenous Vein Grafts
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- Kupreishvili, Koba (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Meischl, Christof (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Vonk, Alexander B. A. (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Stooker, Wim (författare)
- Onze Lieve Vrouwe Gasthuis
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- Eijsman, Leon (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Blom, Anna M. (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
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- Quax, Paul H A (författare)
- Leiden University Medical Centre
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- van Hinsbergh, Victor W M (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Niessen, Hans W M (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Krijnen, Paul A. J. (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Annals of Vascular Surgery. - : Elsevier BV. - 0890-5096. ; 41, s. 259-264
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Complement is an important mediator in arterial blood pressure-induced vein graft failure. Previously, we noted activation of cell protective mechanisms in human saphenous veins too. Here we have analyzed whether C4b-binding protein (C4bp), an endogenous complement inhibitor, is present in the vein wall. Methods: Human saphenous vein segments obtained from patients undergoing coronary artery bypass grafting (n = 55) were perfused in vitro at arterial blood pressure with either autologous blood for 1, 2, 4, or 6 hr or with autologous blood supplemented with reactive oxygen species scavenger N-acetylcysteine. The segments were subsequently analyzed quantitatively for presence of C4bp and complement activation product C3d using immunohistochemistry. Results: Perfusion induced deposition of C3d and C4bp within the media of the vessel wall, which increased reproducibly and significantly over a period of 4 hr up to 3.8% for C3d and 81% for C4bp of the total vessel area. Remarkably after 6 hr of perfusion, the C3d-positive area decreased significantly to 1.3% and the C4bp-positive area to 19% of the total area of the vein. The areas positive for both C4bp and C3d were increased in the presence of N-acetylcysteine. Conclusions: Exposure to arterial blood pressure leads to a transient presence of C4bp in the vein wall. This may be part of a cell-protective mechanism to counteract arterial blood pressure-induced cellular stress and inflammation in grafted veins.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Kupreishvili, Ko ...
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Meischl, Christo ...
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Vonk, Alexander ...
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Stooker, Wim
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Eijsman, Leon
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Blom, Anna M.
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Quax, Paul H A
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van Hinsbergh, V ...
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Niessen, Hans W ...
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Krijnen, Paul A. ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Annals of Vascul ...
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Lunds universitet