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Spatiotemporal sphi...
Spatiotemporal sphingosine-1-phosphate receptor 3 expression within the cerebral vasculature after ischemic stroke
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- Matuskova, Hana (författare)
- Lund University,Lunds universitet,Vaskulär biologi,Forskargrupper vid Lunds universitet,Vascular Biology,Lund University Research Groups,German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Bonn
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- Porschen, Lisa T. (författare)
- Lund University,Lunds universitet,Vaskulär biologi,Forskargrupper vid Lunds universitet,Vascular Biology,Lund University Research Groups,University of Augsburg
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- Matthes, Frank (författare)
- Lund University,Lunds universitet,Vaskulär biologi,Forskargrupper vid Lunds universitet,Vascular Biology,Lund University Research Groups,University of Augsburg
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- Lindgren, Arne G. (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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- Petzold, Gabor C. (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Bonn
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- Meissner, Anja (författare)
- Lund University,Lunds universitet,Vaskulär biologi,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Vascular Biology,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,German Center for Neurodegenerative Diseases (DZNE), Bonn,University of Augsburg
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: iScience. - 2589-0042. ; 27:6
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Sphingosine-1-phosphate receptors (S1PRs) are promising therapeutic targets in cardiovascular disease, including ischemic stroke. However, important spatiotemporal information for alterations of S1PR expression is lacking. Here, we investigated the role of S1PR3 in ischemic stroke in rodent models and patient samples. We show that S1PR3 is acutely upregulated in perilesional reactive astrocytes after stroke, and that stroke volume and behavioral deficits are improved in mice lacking S1PR3. Further, we find that administration of an S1PR3 antagonist at 4-h post-stroke, but not at later timepoints, improves stroke outcome. Lastly, we observed higher plasma S1PR3 concentrations in experimental stroke and in patients with ischemic stroke. Together, our results establish S1PR3 as a potential drug target and biomarker in ischemic stroke.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Biological sciences
- Molecular neuroscience
- Natural sciences
- Neuroscience
- Pathophysiology
- Physiology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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