Sökning: onr:"swepub:oai:lup.lub.lu.se:6f02cc57-787a-46bc-a105-ff5c369bb85b" > Dipyridamole enhanc...
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000 | 05830naa a2200481 4500 | |
001 | oai:lup.lub.lu.se:6f02cc57-787a-46bc-a105-ff5c369bb85b | |
003 | SwePub | |
008 | 230323s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/6f02cc57-787a-46bc-a105-ff5c369bb85b2 URI |
024 | 7 | a https://doi.org/10.1007/s13402-023-00789-72 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Huang, Shanu Shanghai Jiao Tong University4 aut |
245 | 1 0 | a Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner |
264 | c 2023-03-20 | |
264 | 1 | b Springer Science and Business Media LLC,c 2023 |
520 | a PURPOSE: Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secondary strokes. Aspirin is a well-known non-steroid anti-inflammatory drug. This anti-inflammatory property has turned aspirin into a potential drug for inflammation-related cancers such as colorectal cancer (CRC). Here, we aimed to explore whether the anti-cancer effect of aspirin against CRC could be improved by combined administration with dipyridamole.METHODS: Population-based clinical data analysis was conducted to assess a possible therapeutic effect of combined dipyridamole and aspirin treatment in inhibiting CRC compared with either monotherapy. This therapeutic effect was further verified in different CRC mouse models, i.e. an orthotopic xenograft mouse model, an AOM/DSS mouse model, an Apc min/+ mouse model and a patient derived xenograft (PDX) mouse model. The in vitro effects of the drugs on CRC cells were tested using CCK8 and flow cytometry assays. RNA-Seq, Western blotting, qRT-PCR and flow cytometry were used to identify the underlying molecular mechanisms. RESULTS: We found that dipyridamole combined with aspirin had a better inhibitory effect on CRC than either monotherapy alone. The enhanced anti-cancer effect of the combined use of dipyridamole with aspirin was found to rely on the induction of an overwhelmed endoplasmic reticulum (ER) stress and subsequent pro-apoptotic unfolded protein response (UPR), which was different from the anti-platelet effect.CONCLUSIONS: Our data indicate that the anti-cancer effect of aspirin against CRC may be enhanced by combined administration with dipyridamole. In case further clinical studies confirm our findings, these may be repurposed as adjuvant agents. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Zhang, Nai-Qiu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Region Skåne4 aut0 (Swepub:lu)na1267zh |
700 | 1 | a Xu, Chun-Jieu Shanghai Jiao Tong University4 aut |
700 | 1 | a Huang, Wu-Qingu Fujian Medical University4 aut |
700 | 1 | a Li, Dong-Xueu Shanghai Jiao Tong University4 aut |
700 | 1 | a Li, Junu Shanghai Jiao Tong University4 aut |
700 | 1 | a Yao, Lin-Liu Shanghai Jiao Tong University4 aut |
700 | 1 | a Sundquist, Kristinau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Region Skåne,Icahn School of Medicine at Mount Sinai4 aut0 (Swepub:lu)med-ksq |
700 | 1 | a Sundquist, Janu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Region Skåne,Icahn School of Medicine at Mount Sinai4 aut0 (Swepub:lu)med-jsu |
700 | 1 | a Jiang, Shu-Hengu Shanghai Jiao Tong University4 aut |
700 | 1 | a Xing, Xinu Shanghai Fengxian District Central Hospital4 aut |
700 | 1 | a Hu, Li-Pengu Shanghai Jiao Tong University4 aut |
700 | 1 | a Zhang, Zhi-Gangu Shanghai Jiao Tong University4 aut |
700 | 1 | a Ji, Jianguangu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Region Skåne4 aut0 (Swepub:lu)med-jji |
700 | 1 | a Zhang, Xue-Liu Shanghai Jiao Tong University4 aut |
710 | 2 | a Shanghai Jiao Tong Universityb Allmänmedicin och klinisk epidemiologi4 org |
773 | 0 | t Cellular Oncologyd : Springer Science and Business Media LLCg 46:4, s. 953-967q 46:4<953-967x 2211-3428x 2211-3436 |
856 | 4 | u http://dx.doi.org/10.1007/s13402-023-00789-7y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/6f02cc57-787a-46bc-a105-ff5c369bb85b |
856 | 4 8 | u https://doi.org/10.1007/s13402-023-00789-7 |
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