Sökning: onr:"swepub:oai:lup.lub.lu.se:6fbb2a47-e96e-4aa3-b61f-f330c7d04464" >
Sex differences in ...
-
Wood, Madeline E.University of Toronto,Sunnybrook Health Sciences Centre
(författare)
Sex differences in associations between APOE ε2 and longitudinal cognitive decline
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:6fbb2a47-e96e-4aa3-b61f-f330c7d04464
-
https://lup.lub.lu.se/record/6fbb2a47-e96e-4aa3-b61f-f330c7d04464URI
-
https://doi.org/10.1002/alz.13036DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
INTRODUCTION: We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples. METHODS: We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately. RESULTS: In both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE ε3/ε3 carriers, cognitive trajectories did not differ between sexes. There were no sex-specific associations of APOE ε2 with cognition in NHB participants (N = 2010). DISCUSSION: In NHW adults, APOE ε2 may protect men but not women against cognitive decline. Highlights: We studied sex-specific apolipoprotein E (APOE) ε2 effects on cognitive decline. In non-Hispanic White (NHW) adults, APOE ε2 selectively protects men against decline. Among men, APOE ε2 was more protective than APOE ε3/ε3. In women, APOE ε2 was no more protective than APOE ε3/ε3. Among APOE ε2 carriers, men had slower decline than women. There were no sex-specific APOE ε2 effects in non-Hispanic Black (NHB) adults.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Xiong, Lisa Y.University of Toronto,Sunnybrook Health Sciences Centre
(författare)
-
Wong, Yuen YanUniversity of Toronto,Sunnybrook Health Sciences Centre
(författare)
-
Buckley, Rachel F.Melbourne School of Psychological Sciences,Harvard Medical School,University of Melbourne
(författare)
-
Swardfager, WalterSunnybrook Health Sciences Centre,University of Toronto
(författare)
-
Masellis, MarioSunnybrook Health Sciences Centre,University of Toronto
(författare)
-
Lim, Andrew S.P.University of Toronto,Sunnybrook Health Sciences Centre
(författare)
-
Nichols, EmmaJohns Hopkins Bloomberg School of Public Health
(författare)
-
Joie, Renaud LaUniversity of California, San Francisco
(författare)
-
Casaletto, Kaitlin B.University of California, San Francisco
(författare)
-
Kumar, Raj G.Icahn School of Medicine at Mount Sinai
(författare)
-
Dams-O'Connor, KristenIcahn School of Medicine at Mount Sinai
(författare)
-
Palta, PriyaColumbia University
(författare)
-
George, Kristen M.University of California, Davis
(författare)
-
Satizabal, Claudia L.Boston University,University of Texas Health Science Centre
(författare)
-
Barnes, Lisa L.Rush Alzheimer's Disease Center
(författare)
-
Schneider, Julie A.Rush Alzheimer's Disease Center
(författare)
-
Binet, Alexa PichetteLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)al1314pi
(författare)
-
Villeneuve, SylviaMcConnell Brain Imaging Centre,McGill University
(författare)
-
Pa, JudyUniversity of Southern California
(författare)
-
Brickman, Adam M.Columbia University
(författare)
-
Black, Sandra E.Sunnybrook Health Sciences Centre,University of Toronto
(författare)
-
Rabin, Jennifer S.University of Toronto,Sunnybrook Health Sciences Centre
(författare)
-
University of TorontoSunnybrook Health Sciences Centre
(creator_code:org_t)
-
ADNI and Prevent-AD Research Groups
Sammanhörande titlar
-
Ingår i:Alzheimer's and Dementia: Wiley19:10, s. 4651-46611552-52601552-5279
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Wood, Madeline E ...
-
Xiong, Lisa Y.
-
Wong, Yuen Yan
-
Buckley, Rachel ...
-
Swardfager, Walt ...
-
Masellis, Mario
-
visa fler...
-
Lim, Andrew S.P.
-
Nichols, Emma
-
Joie, Renaud La
-
Casaletto, Kaitl ...
-
Kumar, Raj G.
-
Dams-O'Connor, K ...
-
Palta, Priya
-
George, Kristen ...
-
Satizabal, Claud ...
-
Barnes, Lisa L.
-
Schneider, Julie ...
-
Binet, Alexa Pic ...
-
Villeneuve, Sylv ...
-
Pa, Judy
-
Brickman, Adam M ...
-
Black, Sandra E.
-
Rabin, Jennifer ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Alzheimer's and ...
- Av lärosätet
-
Lunds universitet