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Less small-bowel in...
Less small-bowel injury with lumiracoxib compared with naproxen plus omeprazole
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Hawkey, Christopher J (författare)
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Ell, Christian (författare)
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Simon, Bernd (författare)
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Albert, Joerg (författare)
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Keuchel, Martin (författare)
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Mcalindon, Mark (författare)
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Fortun, Paul (författare)
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Schumann, Stefan (författare)
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Bolten, Wolfgang (författare)
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Shonde, Anthony (författare)
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Hugot, Jean-Louis (författare)
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Yu, Vincent (författare)
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Arulmani, Udayasankar (författare)
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Krammer, Gerhard (författare)
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Rebuli, Rosemary (författare)
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- Toth, Ervin (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier BV. - 1542-7714 .- 1542-3565. ; 6:5, s. 536-544
- Relaterad länk:
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http://www.ncbi.nlm....
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http://www.sciencedi...
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background & Aims: The selective cyclooxygenase-2 inhibitor lumiracoxib has been shown to reduce endoscopically detected ulcers and ulcer complications in the upper gastrointestinal tract compared with nonselective nonsteroidal anti-inflammatory drugs. We investigated whether lumiracoxib would reduce small-bowel injury compared with naproxen plus omeprazole. Methods: Healthy volunteers were randomized to receive lumiracoxib, 100 mg once daily, naproxen 500 mg twice daily plus omeprazole 20 mg once daily, or placebo in a 16-day double-blind, parallel-group study. Small-bowel mucosal injury and inflammation were assessed by video capsule endoscopy, the lactulose:L-rhamnose permeability assessment, and the fecal calprotectin test. Results: Of 152 randomized subjects, 139 completed the study with valid video capsule endoscopies (lumiracoxib, n = 47; naproxen plus omeprazole, n = 45; placebo, n = 47). Compared with placebo, an increased number of subjects on naproxen plus omeprazole had small-bowel mucosal breaks (77.8% vs 40.4%, P < .001), with increased permeability (P = .023) and increased fecal calprotectin (increase, 96.8 vs 14.5 mg/kg for placebo; P < .001). With lumiracoxib, 27.7% of subjects had small-bowel mucosal breaks (P = .196 vs placebo; P < .001 vs naproxen), there was no increase in permeability (P = .157 vs placebo; P = .364 vs naproxen), and no increase in fecal calprotectin (-5.7 mg/kg; P = .377 vs placebo; P < .001 vs naproxen). Conclusions: As assessed by 3 different measures, acute small-bowel injury on lumiracoxib treatment is less frequent than with naproxen plus omeprazole and similar to placebo.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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Hawkey, Christop ...
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Ell, Christian
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Simon, Bernd
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Albert, Joerg
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Keuchel, Martin
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Mcalindon, Mark
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visa fler...
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Fortun, Paul
-
Schumann, Stefan
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Bolten, Wolfgang
-
Shonde, Anthony
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Hugot, Jean-Loui ...
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Yu, Vincent
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Arulmani, Udayas ...
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Krammer, Gerhard
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Rebuli, Rosemary
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Toth, Ervin
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Lunds universitet