Sökning: onr:"swepub:oai:lup.lub.lu.se:728be5ae-c0a1-42d4-920b-0c17c838381c" >
DNA methylation cha...
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Lozano, ManuelUniversity of Valencia
(författare)
DNA methylation changes associated with prenatal mercury exposure : A meta-analysis of prospective cohort studies from PACE consortium
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:728be5ae-c0a1-42d4-920b-0c17c838381c
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https://lup.lub.lu.se/record/728be5ae-c0a1-42d4-920b-0c17c838381cURI
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https://doi.org/10.1016/j.envres.2021.112093DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147885973URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (DNAm) by meta-analysis in up to seven independent studies (n = 1462) as well as persistence of those relationships in blood from 7 to 8 year-old children (n = 794). In cord blood, we found limited evidence of differential DNAm at cg24184221 in MED31 (β = 2.28 × 10−4, p-value = 5.87 × 10−5) in relation to prenatal MeHg exposure. In child blood, we identified differential DNAm at cg15288800 (β = 0.004, p-value = 4.97 × 10−5), also located in MED31. This repeated link to MED31, a gene involved in lipid metabolism and RNA Polymerase II transcription function, may suggest a DNAm perturbation related to MeHg exposure that persists into early childhood. Further, we found evidence for association between prenatal MeHg exposure and child blood DNAm levels at two additional CpGs: cg12204245 (β = 0.002, p-value = 4.81 × 10−7) in GRK1 and cg02212000 (β = −0.001, p-value = 8.13 × 10−7) in GGH. Prenatal MeHg exposure was associated with DNAm modifications that may influence health outcomes, such as cognitive or anthropometric development, in different populations.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Yousefi, PaulUniversity of Bristol
(författare)
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Broberg, KarinKarolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups(Swepub:lu)kgen-kbr
(författare)
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Soler-Blasco, RaquelUniversity of Valencia
(författare)
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Miyashita, ChihiroHokkaido University
(författare)
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Pesce, GiancarloUniversity of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)
(författare)
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Kim, Woo JinKangwon National University
(författare)
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Rahman, MohammadHarvard Medical School,Harvard Pilgrim Health Care Institute
(författare)
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Bakulski, Kelly M.University of Michigan
(författare)
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Haug, Line S.Norwegian Institute of Public Health
(författare)
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Ikeda-Araki, AtsukoHokkaido University
(författare)
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Huel, GuyCentre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
(författare)
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Park, JaehyunSeoul National University
(författare)
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Relton, CarolineUniversity of Bristol
(författare)
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Vrijheid, MartinePompeu Fabra University,Centre for Research in Environmental Epidemiology
(författare)
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Rifas-Shiman, SherylHarvard Medical School,Harvard Pilgrim Health Care Institute
(författare)
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Oken, EmilyHarvard Medical School,Harvard Pilgrim Health Care Institute
(författare)
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Dou, John F.University of Michigan
(författare)
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Kishi, ReikoHokkaido University
(författare)
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Gutzkow, Kristine B.Norwegian Institute of Public Health
(författare)
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Annesi-Maesano, IsabellaUniversity of Montpellier
(författare)
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Won, SunghoSeoul National University
(författare)
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Hivert, Marie FranceMassachusetts General Hospital
(författare)
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Fallin, M. DanieleJohns Hopkins Bloomberg School of Public Health
(författare)
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Vafeiadi, MarinaUniversity of Crete Medical School
(författare)
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Ballester, FerranUniversity of Valencia
(författare)
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Bustamante, MarionaPompeu Fabra University,Centre for Research in Environmental Epidemiology
(författare)
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Llop, SabrinaCIBER Epidemiology and Public Health (CIBERESP),University of Valencia
(författare)
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University of ValenciaUniversity of Bristol
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Environmental Research: Elsevier BV2040013-93511096-0953
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Lozano, Manuel
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Yousefi, Paul
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Broberg, Karin
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Soler-Blasco, Ra ...
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Miyashita, Chihi ...
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Pesce, Giancarlo
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visa fler...
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Kim, Woo Jin
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Rahman, Mohammad
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Bakulski, Kelly ...
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Haug, Line S.
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Ikeda-Araki, Ats ...
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Huel, Guy
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Park, Jaehyun
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Relton, Caroline
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Vrijheid, Martin ...
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Rifas-Shiman, Sh ...
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Oken, Emily
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Dou, John F.
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Kishi, Reiko
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Gutzkow, Kristin ...
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Annesi-Maesano, ...
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Won, Sungho
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Hivert, Marie Fr ...
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Fallin, M. Danie ...
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Vafeiadi, Marina
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Ballester, Ferra ...
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Bustamante, Mari ...
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Llop, Sabrina
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
- Artiklar i publikationen
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Environmental Re ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet