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Matrix Metalloprote...
Matrix Metalloproteinase-8 Activity is Increased in Type 1 Diabetes Children with High-Risk Diabetes HLA and Systemic Inflammation
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- Liuba, P. (författare)
- Lund University,Lunds universitet,Barnkardiologi,Forskargrupper vid Lunds universitet,Children cardiology,Lund University Research Groups,Skåne University Hospital
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- Odermarsky, M. (författare)
- Lund University,Lunds universitet,Barnkardiologi,Forskargrupper vid Lunds universitet,Children cardiology,Lund University Research Groups,Skåne University Hospital
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- Pussinen, P. (författare)
- Skåne University Hospital
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- Sorsa, T. (författare)
- Skåne University Hospital
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- Maxedius, A. (författare)
- Lund University,Lunds universitet,Barnkardiologi,Forskargrupper vid Lunds universitet,Children cardiology,Lund University Research Groups
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(creator_code:org_t)
- 2012
- 2012
- Engelska 2 s.
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Ingår i: Cardiology in the Young. - 1467-1107. ; 22:S1, s. 115-116
- Relaterad länk:
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http://www.uni-kiel.... (free)
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) are colocalized to lipid-laden macrophages, and play a central role in initiation and propagation of chronic vascular diseases including atherosclerosis. Prior cross-sectional studies from our centre on children and adolescents with type 1 diabetes suggested possible propensity conferred by diabetes-risk HLA DQ2/8, particularly in an inflammatory milieu, to peripheral vascular dysfunction, an important precursor of atherosclerosis. In the same population, we aimed to assess whether this putative interplay between DQ2/8 and inflammation also reflects into increased activity of MMP and MPO. Methods: Blood pressure, inflammatory, lipid, HbA1c, cyclic guanilate monophospate (cGMP), along with degree of exposure to secondhand tobacco smoke (STS) were determined in 74 children and adolescents with type 1 diabetes at baseline and 1 year later. MMP-8 and MPO levels were measured only at the 2nd time-point. Results: In univariate regression, baseline BMI, HbA1c, CRP(log), and TC/HDL were all predictors of 1-year MMP-2 (p,.05 for all), while exposure to STS, BMI, cGMP, and TC/ HDL predicted levels of MPO (p,.05 for all). The rise in serum MMP-8 was most increased in those with both DQ2/8 and CRP .1 mg/l (p=0.01), but no such difference was noted with regard to MPO. Conclusion: In young patients with type 1 diabetes, increased activities of MMP and MPO appear to relate mainly to dyslipidemia, but inflammation, particularly in those with diabetes-risk HLA, and exposure to tobacco smoke could be important stimuli as well.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- neutrophil collagenase
- lipid
- hemoglobin A1c
- cyclic GMP
- matrix metalloproteinase
- myeloperoxidase
- tobacco smoke
- high density lipoprotein
- gelatinase A
- insulin dependent diabetes mellitus
- child
- human
- risk
- diabetes mellitus
- HLA system
- inflammation
- cardiology
- Japanese (people)
- society
- pediatric cardiology
- heart surgery
- exposure
- adolescent
- atherosclerosis
- blood pressure
- population
- precursor
- dyslipidemia
- cross-sectional study
- patient
- serum
- stimulus
- vascular disease
- macrophage
- passive smoking
Publikations- och innehållstyp
- kon (ämneskategori)
- ref (ämneskategori)
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