Sökning: onr:"swepub:oai:lup.lub.lu.se:73011e4a-ec91-4c36-9c08-249e50996c89" > Coffee and tea cons...
Fältnamn | Indikatorer | Metadata |
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000 | 07127naa a2201081 4500 | |
001 | oai:lup.lub.lu.se:73011e4a-ec91-4c36-9c08-249e50996c89 | |
003 | SwePub | |
008 | 160401s2014 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-84217 | |
009 | oai:prod.swepub.kib.ki.se:129043865 | |
024 | 7 | a https://lup.lub.lu.se/record/45586582 URI |
024 | 7 | a https://doi.org/10.1002/ijc.286552 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-842172 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1290438652 URI |
040 | a (SwePub)lud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Dik, Vincent K.4 aut |
245 | 1 0 | a Coffee and tea consumption, genotype- based CYP1A2 and NAT2 activity and colorectal cancer risk- Results from the EPIC cohort study |
264 | c 2013-12-21 | |
264 | 1 | b Wiley,c 2014 |
520 | a Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female) of the European Investigation into Cancer and Nutrition (EPIC) cohort study were analyzed. At baseline (1992-2000) habitual (total, caffeinated and decaffeinated) coffee and tea consumption was assessed with dietary questionnaires. Cox proportional hazards models were used to estimate adjusted hazard ratio's (HR) and 95% confidence intervals (95% CI). Potential effect modification by genotype-based CYP1A2 and NAT2 activity was studied in a nested case-control set of 1,252 cases and 2,175 controls. After a median follow-up of 11.6 years, 4,234 participants developed CRC (mean age 64.78.3 years). Total coffee consumption (high vs. non/low) was not associated with CRC risk (HR 1.06, 95% CI 0.95-1.18) or subsite cancers, and no significant associations were found for caffeinated (HR 1.10, 95% CI 0.97-1.26) and decaffeinated coffee (HR 0.96, 95% CI 0.84-1.11) and tea (HR 0.97, 95% CI 0.86-1.09). High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non/low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity, which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk. This study shows that coffee and tea consumption is not likely to be associated with overall CRC. What's new? Coffee and tea contain numerous compounds that may protect against colorectal cancer (CRC). In this study of more than 475,000 participants over more than a decade, the authors investigated whether coffee or tea consumption is associated with an altered risk of developing CRC. They also asked whether genetic variations in two enzymes involved in caffeine metabolism (CYP1A2 and NAT2) might affect this risk. They conclude that neither consumption patterns, nor genetic differences in caffeine metabolism, appear to have a significant impact on CRC risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a Colorectal cancer | |
653 | a coffee | |
653 | a tea | |
653 | a CYP1A2 | |
653 | a NAT2 | |
700 | 1 | a Bueno-de-Mesquita, H. B(as)4 aut |
700 | 1 | a Van Oijen, Martijn G. H.4 aut |
700 | 1 | a Siersema, Peter D.4 aut |
700 | 1 | a Uiterwaal, Cuno S. P. M.4 aut |
700 | 1 | a Van Gils, Carla H.4 aut |
700 | 1 | a Van Duijnhoven, Fraenzel J. B.4 aut |
700 | 1 | a Cauchi, Stephane4 aut |
700 | 1 | a Yengo, Loic4 aut |
700 | 1 | a Froguel, Philippe4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Bech, Bodil H.4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Olsen, Anja4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Racine, Antoine4 aut |
700 | 1 | a Fagherazzi, Guy4 aut |
700 | 1 | a Kuehn, Tilman4 aut |
700 | 1 | a Campa, Daniele4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Aleksandrova, Krasimira4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Peppa, Eleni4 aut |
700 | 1 | a Oikonomou, Eleni4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Grioni, Sara4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Tumino, Rosaria4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Peeters, Petra H. M.4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Engeset, Dagrun4 aut |
700 | 1 | a Braaten, Tonje4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Chirlaque, Maria-Doloresu nutrition4 aut |
700 | 1 | a Sanchez, Maria-Jose4 aut |
700 | 1 | a Barricarte, Aurelio4 aut |
700 | 1 | a Zamora-Ros, Raul4 aut |
700 | 1 | a Argueelles, Marcial4 aut |
700 | 1 | a Jirström, Karinu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-kji |
700 | 1 | a Wallström, Peteru Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)pe6853wa |
700 | 1 | a Nilsson, Lena Maria,d 1965-u Umeå universitet,Näringsforskning,Arktiskt centrum vid Umeå universitet (Arcum)4 aut0 (Swepub:umu)leni0002 |
700 | 1 | a Ljuslinder, Ingridu Umeå universitet,Onkologi,Arktiskt centrum vid Umeå universitet (Arcum)4 aut0 (Swepub:umu)inlj0001 |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Wareham, Nick4 aut |
700 | 1 | a Freisling, Heinz4 aut |
700 | 1 | a Licaj, Idlir4 aut |
700 | 1 | a Jenab, Mazda4 aut |
700 | 1 | a Gunter, Marc J.4 aut |
700 | 1 | a Murphy, Neil4 aut |
700 | 1 | a Romaguera-Bosch, Dora4 aut |
700 | 1 | a Riboli, Elio4 aut |
710 | 2 | a Karolinska Institutetb nutrition4 org |
773 | 0 | t International Journal of Cancerd : Wileyg 135:2, s. 401-412q 135:2<401-412x 0020-7136x 1097-0215 |
856 | 4 | u http://dx.doi.org/10.1002/ijc.28655y FULLTEXT |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.28655 |
856 | 4 8 | u https://lup.lub.lu.se/record/4558658 |
856 | 4 8 | u https://doi.org/10.1002/ijc.28655 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84217 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:129043865 |
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