Sökning: onr:"swepub:oai:lup.lub.lu.se:74bd0687-9fd0-433c-aa55-f7ae8cd24fd3" > A Federated Databas...
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000 | 07047naa a2200901 4500 | |
001 | oai:lup.lub.lu.se:74bd0687-9fd0-433c-aa55-f7ae8cd24fd3 | |
003 | SwePub | |
008 | 240628s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/74bd0687-9fd0-433c-aa55-f7ae8cd24fd32 URI |
024 | 7 | a https://doi.org/10.3390/life140202622 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Delfin, Carlu Novo Nordisk A/S4 aut |
245 | 1 0 | a A Federated Database for Obesity Research : An IMI-SOPHIA Study |
264 | 1 | c 2024 |
520 | a Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challenges to achieving these goals is that many clinical cohorts are siloed, limiting the potential of combined data for biomarker discovery. In SOPHIA, we have addressed this challenge by setting up a federated database building on open-source DataSHIELD technology. The database currently federates 16 cohorts that are accessible via a central gateway. The database is multi-modal, including research studies, clinical trials, and routine health data, and is accessed using the R statistical programming environment where statistical and machine learning analyses can be performed at a distance without any disclosure of patient-level data. We demonstrate the use of the database by providing a proof-of-concept analysis, performing a federated linear model of BMI and systolic blood pressure, pooling all data from 16 studies virtually without any analyst seeing individual patient-level data. This analysis provided similar point estimates compared to a meta-analysis of the 16 individual studies. Our approach provides a benchmark for reproducible, safe federated analyses across multiple study types provided by multiple stakeholders. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a bioinformatics | |
653 | a federated database system | |
653 | a obesity | |
653 | a remote statistical analysis | |
653 | a risk prediction | |
700 | 1 | a Dragan, Iulianu Swiss Institute for Bioinformatics (SIB)4 aut |
700 | 1 | a Kuznetsov, Dmitryu Swiss Institute for Bioinformatics (SIB)4 aut |
700 | 1 | a Tajes, Juan Fernandezu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)ju3355fe |
700 | 1 | a Smit, Femkeu Maastricht University4 aut |
700 | 1 | a Coral, Daniel E.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)da1078co |
700 | 1 | a Farzaneh, Aliu Erasmus University Medical Center4 aut |
700 | 1 | a Haugg, Andréu Boehringer Ingelheim GmbH4 aut |
700 | 1 | a Hungele, Andreasu German Center for Diabetes Research4 aut |
700 | 1 | a Niknejad, Anneu Swiss Institute for Bioinformatics (SIB)4 aut |
700 | 1 | a Hall, Christopheru University of Dundee4 aut |
700 | 1 | a Jacobs, Daan4 aut |
700 | 1 | a Marek, Dianau Swiss Institute for Bioinformatics (SIB)4 aut |
700 | 1 | a Fraser, Diane P.u University of Exeter4 aut |
700 | 1 | a Thuillier, Dorothee4 aut |
700 | 1 | a Ahmadizar, Faribau University Medical Center Utrecht4 aut |
700 | 1 | a Mehl, Florenceu Swiss Institute for Bioinformatics (SIB)4 aut |
700 | 1 | a Pattou, Francois4 aut |
700 | 1 | a Burdet, Fredericu Swiss Institute for Bioinformatics (SIB)4 aut |
700 | 1 | a Hawkes, Garethu University of Exeter4 aut |
700 | 1 | a Arts, Ilja C.W.u Maastricht University4 aut |
700 | 1 | a Blanch, Jordiu Catalan Institute Of Health4 aut |
700 | 1 | a Van Soest, Johanu Maastricht University,Yukioka Hospital4 aut |
700 | 1 | a Fernández-Real, José Manuelu Girona Biomedical Research Institute (IDIBGI),Hospital Universitari de Girona Dr. Josep Trueta,University of Girona,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)4 aut |
700 | 1 | a Boehl, Juergenu Boehringer Ingelheim GmbH4 aut |
700 | 1 | a Fink, Katharinau German Center for Diabetes Research4 aut |
700 | 1 | a van Greevenbroek, Marleen M.J.u Maastricht University Medical Centre4 aut |
700 | 1 | a Kavousi, Maryamu Erasmus University Medical Center4 aut |
700 | 1 | a Minten, Michielu Maastricht University4 aut |
700 | 1 | a Prinz, Nicoleu German Center for Diabetes Research4 aut |
700 | 1 | a Ipsen, Nielsu Novo Nordisk A/S4 aut |
700 | 1 | a Franks, Paul W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Ramos, Rafaelu University of Girona,Erasmus University Medical Center4 aut |
700 | 1 | a Holl, Reinhard W.u University of Ulm,German Center for Diabetes Research4 aut |
700 | 1 | a Horban, Scottu University of Dundee4 aut |
700 | 1 | a Duarte-Salles, Talitau Erasmus University Medical Center4 aut |
700 | 1 | a Tran, Van Du T.u Swiss Institute for Bioinformatics (SIB)4 aut |
700 | 1 | a Raverdy, Violeta4 aut |
700 | 1 | a Leal, Yennyu Hospital Universitari de Girona Dr. Josep Trueta,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),University of Girona,Girona Biomedical Research Institute (IDIBGI)4 aut |
700 | 1 | a Lenart, Adamu Novo Nordisk A/S4 aut |
700 | 1 | a Pearson, Ewanu University of Dundee4 aut |
700 | 1 | a Sparsø, Thomasu Novo Nordisk A/S4 aut |
700 | 1 | a Giordano, Giuseppe N.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-geg |
700 | 1 | a Ioannidis, Vassiliosu Swiss Institute for Bioinformatics (SIB)4 aut |
700 | 1 | a Soh, Kengu Novo Nordisk A/S4 aut |
700 | 1 | a Frayling, Timothy M.u University of Geneva Medical School,University of Exeter4 aut |
700 | 1 | a Le Roux, Carel W.u University College Dublin4 aut |
700 | 1 | a Ibberson, Marku Swiss Institute for Bioinformatics (SIB)4 aut |
710 | 2 | a Novo Nordisk A/Sb Swiss Institute for Bioinformatics (SIB)4 org |
773 | 0 | t Lifeg 14:2q 14:2x 0024-3019 |
856 | 4 | u http://dx.doi.org/10.3390/life14020262x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/74bd0687-9fd0-433c-aa55-f7ae8cd24fd3 |
856 | 4 8 | u https://doi.org/10.3390/life14020262 |
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