Sökning: onr:"swepub:oai:lup.lub.lu.se:77102f37-8032-48f2-a4f3-d6469c83ca21" > The impact of endur...
Fältnamn | Indikatorer | Metadata |
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000 | 04873naa a2200577 4500 | |
001 | oai:lup.lub.lu.se:77102f37-8032-48f2-a4f3-d6469c83ca21 | |
003 | SwePub | |
008 | 191206s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/77102f37-8032-48f2-a4f3-d6469c83ca212 URI |
024 | 7 | a https://doi.org/10.1007/s11682-019-00198-12 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Rauchmann, Boris Stephanu Ludwig-Maximilian University of Munich4 aut |
245 | 1 0 | a The impact of endurance training and table soccer on brain metabolites in schizophrenia |
264 | c 2019-11-05 | |
264 | 1 | b Springer Science and Business Media LLC,c 2020 |
300 | a 12 s. | |
520 | a Higher glutamate and glutamine (together: Glx) and lower N-acetyl-aspartate (NAA) levels were reported in schizophrenia. Endurance training normalizes NAA in the hippocampus, but its effects on other metabolites in the brain and the relationship of metabolites to clinical symptoms remain unknown. For 12 weeks, 20 schizophrenia inpatients (14 men, 6 women) and 23 healthy controls (16 men, 7 women) performed endurance training and a control group of 21 schizophrenia inpatients (15 men, 6 women) played table soccer. A computer-assisted cognitive performance training program was introduced after 6 weeks. We assessed cognitive performance, psychopathological symptoms, and everyday functioning at baseline and after 6 and 12 weeks and performed single voxel magnetic resonance spectroscopy of the hippocampus, left dorsolateral prefrontal cortex (DLPFC), and thalamus. We quantified NAA, Glx, total creatine (tCr), calculated NAA/tCr and Glx/tCr and correlated these ratios with physical fitness, clinical and neurocognitive scores, and everyday functioning. At baseline, in both schizophrenia groups NAA/tCr was lower in the left DLPFC and left hippocampus and Glx/tCr was lower in the hippocampus than in the healthy controls. After 6 weeks, NAA/tCr increased in the left DLPFC in both schizophrenia groups. Brain metabolites did not change significantly in the hippocampus or thalamus, but the correlation between NAA/tCr and Glx/tCr normalized in the left DLPFC. Global Assessment of Functioning improvements correlated with NAA/tCr changes in the left DLPFC. In our study, endurance training and table soccer induced normalization of brain metabolite ratios in the brain circuitry associated with neuronal and synaptic elements, including metabolites of the glutamatergic system. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a NATURVETENSKAPx Fysikx Annan fysik0 (SwePub)103992 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Physical Sciencesx Other Physics Topics0 (SwePub)103992 hsv//eng |
653 | a Aerobic exercise | |
653 | a Clinical symptoms | |
653 | a Glx | |
653 | a MRS | |
653 | a NAA | |
653 | a Schizophrenia | |
700 | 1 | a Ghaseminejad, Farhadu University of British Columbia4 aut |
700 | 1 | a Keeser, Danielu Ludwig-Maximilian University of Munich4 aut |
700 | 1 | a Keller-Varady, Katrionau Ludwig-Maximilian University of Munich4 aut |
700 | 1 | a Schneider-Axmann, Thomasu Ludwig-Maximilian University of Munich4 aut |
700 | 1 | a Takahashi, Shunu Wakayama Medical College,Ludwig-Maximilian University of Munich4 aut |
700 | 1 | a Karali, Temmuzu Ludwig-Maximilian University of Munich4 aut |
700 | 1 | a Helms, Guntheru Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-guh |
700 | 1 | a Dechent, Peteru University Medical Center Göttingen4 aut |
700 | 1 | a Maurus, Isabelu Ludwig-Maximilian University of Munich4 aut |
700 | 1 | a Hasan, Alkomietu Ludwig-Maximilian University of Munich4 aut |
700 | 1 | a Wobrock, Thomasu University of Göttingen4 aut |
700 | 1 | a Ertl-Wagner, Birgitu Hospital for Sick Children, Toronto,Ludwig-Maximilian University of Munich4 aut |
700 | 1 | a Schmitt, Andreau University of São Paulo,Ludwig-Maximilian University of Munich4 aut |
700 | 1 | a Malchow, Berendu Universitätsklinikum Jena4 aut |
700 | 1 | a Falkai, Peteru Ludwig-Maximilian University of Munich4 aut |
710 | 2 | a Ludwig-Maximilian University of Munichb University of British Columbia4 org |
773 | 0 | t Brain Imaging and Behaviord : Springer Science and Business Media LLCg 14:2, s. 515-526q 14:2<515-526x 1931-7557x 1931-7565 |
856 | 4 | u http://dx.doi.org/10.1007/s11682-019-00198-1y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/77102f37-8032-48f2-a4f3-d6469c83ca21 |
856 | 4 8 | u https://doi.org/10.1007/s11682-019-00198-1 |
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