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Directed vaccinatio...
Directed vaccination against pneumococcal disease
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- Li, Yi (författare)
- The State University of New York
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- Hill, Andrew (författare)
- Abcombi Biosciences Inc.
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- Beitelshees, Marie (författare)
- The State University of New York
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visa fler...
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- Shao, Shuai (författare)
- The State University of New York
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- Lovell, Jonathan F (författare)
- The State University of New York
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- Davidson, Bruce A (författare)
- The State University of New York
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- Knight, Paul R (författare)
- The State University of New York
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- Hakansson, Anders P (författare)
- Lund University,Lunds universitet,Experimentell infektionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Experimental Infection Medicine, Malmö,Lund University Research Groups,The State University of New York
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- Pfeifer, Blaine A (författare)
- The State University of New York
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- Jones, Charles H (författare)
- Abcombi Biosciences Inc.
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The State University of New York Abcombi Biosciences Inc (creator_code:org_t)
- 2016-06-06
- 2016
- Engelska 6 s.
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Ingår i: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 113:25, s. 6898-6903
- Relaterad länk:
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10...
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https://www.pnas.org...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of disease transition from bacterial carriage to infection with the pneumococcus serving as a model organism. Using conserved surface proteins highly expressed during virulent transition, the vaccine mounts an immune response specifically against disease-causing bacterial populations without affecting carriage. Aided by a delivery technology capable of multivalent surface display, which can be adapted easily to a changing clinical picture, results include complete protection against the development of pneumonia and sepsis during animal challenge experiments with multiple, highly variable, and clinically relevant pneumococcal isolates. The approach thus offers a unique and dynamic treatment option readily adaptable to other commensal pathogens.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Li, Yi
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Hill, Andrew
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Beitelshees, Mar ...
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Shao, Shuai
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Lovell, Jonathan ...
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Davidson, Bruce ...
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visa fler...
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Knight, Paul R
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Hakansson, Ander ...
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Pfeifer, Blaine ...
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Jones, Charles H
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Lunds universitet