Obesity and the risk of cardiometabolic diseases

Valenzuela, Pedro L.University of Alcalá,12 de Octubre University Hospital (författare)

The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders. In this Review, we present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardiometabolic consequences and discuss the major mechanisms involved in the association between obesity and the risk of cardiometabolic diseases. We also examine the role of potential moderators of this association, with evidence for and against the so-called ‘metabolically healthy obesity phenotype’, the ‘fatness but fitness’ paradox or the ‘obesity paradox’. Although maintenance of optimal cardiometabolic status should be a primary goal in individuals with obesity, losing body weight and, particularly, excess visceral adiposity seems to be necessary to minimize the risk of cardiometabolic diseases.

Carrera-Bastos, PedroLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,European University of Madrid(Swepub:lu)med-pc_ (författare)
Castillo-García, AdriánUniversity of Alcalá (författare)
Lieberman, Daniel E.Harvard University (författare)
Santos-Lozano, Alejandro12 de Octubre University Hospital,European University Miguel de Cervantes (författare)
Lucia, AlejandroEuropean University of Madrid (författare)
University of Alcalá12 de Octubre University Hospital (creator_code:org_t)

Ingår i:Nature Reviews Cardiology: Springer Science and Business Media LLC20:7, s. 475-4941759-50021759-5010

Av författaren/redakt...: Valenzuela, Pedr ...; Carrera-Bastos, ...; Castillo-García, ...; Lieberman, Danie ...; Santos-Lozano, A ...; Lucia, Alejandro

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