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Distinction of lymp...
Distinction of lymphoid and myeloid clonal hematopoiesis
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- Niroula, Abhishek (författare)
- Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Dana-Farber Cancer Institute,Broad Institute
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- Sekar, Aswin (författare)
- Dana-Farber Cancer Institute
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- Murakami, Mark A. (författare)
- Dana-Farber Cancer Institute
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- Trinder, Mark (författare)
- University of British Columbia,Broad Institute
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- Agrawal, Mridul (författare)
- Dana-Farber Cancer Institute
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- Wong, Waihay J. (författare)
- Broad Institute
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- Bick, Alexander G. (författare)
- Broad Institute,Vanderbilt University
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- Uddin, Md Mesbah (författare)
- Broad Institute,Massachusetts General Hospital
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- Gibson, Christopher J. (författare)
- Dana-Farber Cancer Institute,Broad Institute
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- Griffin, Gabriel K. (författare)
- Broad Institute
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- Honigberg, Michael C. (författare)
- Broad Institute,Massachusetts General Hospital
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- Zekavat, Seyedeh M. (författare)
- Broad Institute,Yale University
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- Paruchuri, Kaavya (författare)
- Harvard Medical School,Massachusetts General Hospital,Broad Institute
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- Natarajan, Pradeep (författare)
- Broad Institute,Harvard Medical School,Massachusetts General Hospital
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- Ebert, Benjamin L. (författare)
- Broad Institute,Howard Hughes Medical Institute,Dana-Farber Cancer Institute
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(creator_code:org_t)
- 2021-10-18
- 2021
- Engelska.
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:11, s. 1921-1927
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal expansion of blood cells. Somatic gene mutations associated with hematologic malignancies detected in hematopoietic cells of healthy individuals, referred to as CH of indeterminate potential (CHIP), have been associated with myeloid malignancies, while mosaic chromosomal alterations (mCAs) have been associated with lymphoid malignancies. Here, we analyzed CHIP in 55,383 individuals and autosomal mCAs in 420,969 individuals with no history of hematologic malignancies in the UK Biobank and Mass General Brigham Biobank. We distinguished myeloid and lymphoid somatic gene mutations, as well as myeloid and lymphoid mCAs, and found both to be associated with risk of lineage-specific hematologic malignancies. Further, we performed an integrated analysis of somatic alterations with peripheral blood count parameters to stratify the risk of incident myeloid and lymphoid malignancies. These genetic alterations can be readily detected in clinical sequencing panels and used with blood count parameters to identify individuals at high risk of developing hematologic malignancies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- ref (ämneskategori)
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Niroula, Abhishe ...
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Sekar, Aswin
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Murakami, Mark A ...
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Trinder, Mark
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Agrawal, Mridul
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Wong, Waihay J.
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visa fler...
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Bick, Alexander ...
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Uddin, Md Mesbah
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Gibson, Christop ...
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Griffin, Gabriel ...
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Honigberg, Micha ...
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Zekavat, Seyedeh ...
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Paruchuri, Kaavy ...
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Natarajan, Prade ...
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Ebert, Benjamin ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Nature Medicine
- Av lärosätet
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Lunds universitet