Sökning: onr:"swepub:oai:lup.lub.lu.se:79ef5c8a-b0e1-4d71-ba6d-27cc3e00a042" >
Evaluation of Diffu...
-
Karlsson, MichaelLund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups,Copenhagen University Hospital,Cochin Hospital
(författare)
Evaluation of Diffusion Tensor Imaging and Fluid Based Biomarkers in a Large Animal Trial of Cyclosporine in Focal Traumatic Brain Injury
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
-
Mary Ann Liebert Inc,2021
-
9 s.
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:79ef5c8a-b0e1-4d71-ba6d-27cc3e00a042
-
https://lup.lub.lu.se/record/79ef5c8a-b0e1-4d71-ba6d-27cc3e00a042URI
-
https://doi.org/10.1089/neu.2020.7317DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
All phase III trials evaluating medical treatments for traumatic brain injury (TBI), performed to date, have failed. To facilitate future success there is a need for novel outcome metrics that can bridge pre-clinical studies to clinical proof of concept trials. Our objective was to assess diffusion tensor imaging (DTI) and biofluid-based biomarkers as efficacy outcome metrics in a large animal study evaluating the efficacy of cyclosporine in TBI. This work builds on our previously published study that demonstrated a reduced volume of injury by 35% with cyclosporine treatment based on magnetic resonance imaging (MRI) results. A focal contusion injury was induced in piglets using a controlled cortical impact (CCI) device. Cyclosporine in a novel Cremophor/Kolliphor EL-free lipid emulsion, NeuroSTAT, was administered by continuous intravenous infusion for 5 days. The animals underwent DTI on day 5. Glial fibrillary acidic protein (GFAP), as a measure of astroglia injury, and neurofilament light (NF-L), as a measure of axonal injury, were measured in blood on days 1, 2, and 5, and in cerebrospinal fluid (CSF) on day 5 post-injury. Normalized fractional anisotropy (FA) was significantly (p = 0.027) higher in in the treatment group, indicating preserved tissue integrity with treatment. For the biomarkers, we observed a statistical trend of a decreased level of NF-L in CSF (p = 0.051), in the treatment group relative to placebo, indicating less axonal injury. Our findings suggest that DTI, and possibly CSF NF-L, may be feasible as translational end-points assessing neuroprotective drugs in TBI.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Yang, ZhihuiFlorida Museum Natural History
(författare)
-
Chawla, SanjeevCochin Hospital
(författare)
-
Delso, NileCochin Hospital
(författare)
-
Pukenas, BryanCochin Hospital
(författare)
-
Elmér, EskilLund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups,Abliva AB(Swepub:lu)expb-eel
(författare)
-
Hugerth, MatildaAbliva AB
(författare)
-
Margulies, Susan S.Georgia Institute of Technology
(författare)
-
Ehinger, JohannesLund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups(Swepub:lu)med-jeg
(författare)
-
Hansson, Magnus J.Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups,Abliva AB(Swepub:lu)expb-mha
(författare)
-
Wang, Kevin K.W.Florida Museum Natural History
(författare)
-
Kilbaugh, Todd J.Cochin Hospital
(författare)
-
Mitokondriell MedicinForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of Neurotrauma: Mary Ann Liebert Inc38:13, s. 1870-18780897-71511557-9042
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Karlsson, Michae ...
-
Yang, Zhihui
-
Chawla, Sanjeev
-
Delso, Nile
-
Pukenas, Bryan
-
Elmér, Eskil
-
visa fler...
-
Hugerth, Matilda
-
Margulies, Susan ...
-
Ehinger, Johanne ...
-
Hansson, Magnus ...
-
Wang, Kevin K.W.
-
Kilbaugh, Todd J ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
Journal of Neuro ...
- Av lärosätet
-
Lunds universitet