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Glycosylation of ty...
Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis.
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- Bäcklund, Johan (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Treschow, Alexandra (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Bockermann, Robert (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Holm, Björn (författare)
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Holm, Lotta (författare)
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Issazadeh-Navikas, Shohreh (författare)
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Kihlberg, Jan (författare)
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- Holmdahl, Rikard (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: European Journal of Immunology. - 1521-4141. ; 32:12, s. 3776-3784
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Type II collagen (CII) is a candidate cartilage-specific autoantigen, which can become post-translationally modified by hydroxylation and glycosylation. T cell recognition of CII is essential for the development of murine collagen-induced arthritis (CIA) and also occurs in rheumatoid arthritis (RA). The common denominator of murine CIA and human RA is the presentation of an immunodominant CII-derived glycosylated peptide on murine Aq and human DR4 molecules, respectively. To investigate the importance of T cell recognition of glycosylated CII in CIA development after immunization with heterologous CII, we treated neonatal mice with different heterologous CII-peptides (non-modified, hydroxylated and galactosylated). Treatment with the galactosylated peptide (galactoseat position 264) was superior in protecting mice from CIA. Protection was accompanied by a reduced antibody response to CII and by an impaired T cell response to the glycopeptide. To investigate the importance of glycopeptide recognition in an autologous CIA model, we treated MMC-transgenic mice, which express the heterologous CII epitope with a glutamic acid in position 266 in cartilage, with CII-peptides. Again, a strong vaccination potential of the glycopeptide was seen. Hence CII-glycopeptides may be the optimal choice of vaccination target in RA, since humans share the same epitope as the MMC mouse
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Mice
- Male
- Immune Tolerance
- Human
- Glycosylation
- Female
- Inbred C3H
- Non-U.S. Gov't
- T-Lymphocytes: immunology
- Transgenic
- Collagen Type II: genetics
- Collagen Type II: chemistry
- Autoimmunity
- Rheumatoid: immunology
- Support
- Cross Reactions
- Collagen Type II: immunology
- Arthritis
- Animal
- Experimental: immunology
- Experimental: metabolism
- Experimental: pathology
- Rheumatoid: etiology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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