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Biomarkers of rapid...
Biomarkers of rapid chronic kidney disease progression in type 2 diabetes.
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Looker, Helen C (författare)
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Colombo, Marco (författare)
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Hess, Sibylle (författare)
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visa fler...
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Brosnan, Mary J (författare)
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Farran, Bassam (författare)
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Dalton, R Neil (författare)
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Wong, Max C (författare)
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Turner, Charles (författare)
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Palmer, Colin N A (författare)
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Nogoceke, Everson (författare)
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Salomaa, Veikko (författare)
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Dunger, David B (författare)
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Agakov, Felix (författare)
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McKeigue, Paul M (författare)
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Colhoun, Helen M (författare)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
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Ingår i: Kidney International. - : Elsevier BV. - 1523-1755 .- 0085-2538. ; 88:4, s. 888-896
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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http://www.kidney-in...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Here we evaluated the performance of a large set of serum biomarkers for the prediction of rapid progression of chronic kidney disease (CKD) in patients with type 2 diabetes. We used a case-control design nested within a prospective cohort of patients with baseline eGFR 30-60 ml/min per 1.73 m(2). Within a 3.5-year period of Go-DARTS study patients, 154 had over a 40% eGFR decline and 153 controls maintained over 95% of baseline eGFR. A total of 207 serum biomarkers were measured and logistic regression was used with forward selection to choose a subset that were maximized on top of clinical variables including age, gender, hemoglobin A1c, eGFR, and albuminuria. Nested cross-validation determined the best number of biomarkers to retain and evaluate for predictive performance. Ultimately, 30 biomarkers showed significant associations with rapid progression and adjusted for clinical characteristics. A panel of 14 biomarkers increased the area under the ROC curve from 0.706 (clinical data alone) to 0.868. Biomarkers selected included fibroblast growth factor-21, the symmetric to asymmetric dimethylarginine ratio, β2-microglobulin, C16-acylcarnitine, and kidney injury molecule-1. Use of more extensive clinical data including prebaseline eGFR slope improved prediction but to a lesser extent than biomarkers (area under the ROC curve of 0.793). Thus we identified several novel associations of biomarkers with CKD progression and the utility of a small panel of biomarkers to improve prediction.Kidney International advance online publication, 22 July 2015; doi:10.1038/ki.2015.199.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Looker, Helen C
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Colombo, Marco
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Hess, Sibylle
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Brosnan, Mary J
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Farran, Bassam
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Dalton, R Neil
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visa fler...
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Wong, Max C
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Turner, Charles
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Palmer, Colin N ...
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Nogoceke, Everso ...
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Groop, Leif
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Salomaa, Veikko
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Dunger, David B
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Agakov, Felix
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McKeigue, Paul M
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Colhoun, Helen M
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Kidney Internati ...
- Av lärosätet
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Lunds universitet