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Plasma protein N-gl...
Plasma protein N-glycome composition associates with postprandial lipaemic response
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- Louca, Panayiotis (författare)
- St Thomas' Hospital
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Štambuk, Tamara (författare)
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Frkatović-Hodžić, Azra (författare)
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- Nogal, Ana (författare)
- St Thomas' Hospital
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- Mangino, Massimo (författare)
- St Thomas' Hospital
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- Berry, Sarah E. (författare)
- King's College London
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Deriš, Helena (författare)
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Hadjigeorgiou, George (författare)
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Wolf, Jonathan (författare)
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Vinicki, Martina (författare)
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- Franks, Paul W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Valdes, Ana M. (författare)
- University of Nottingham
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- Spector, Tim D. (författare)
- St Thomas' Hospital
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- Lauc, Gordan (författare)
- University of Zagreb
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- Menni, Cristina (författare)
- St Thomas' Hospital
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: BMC Medicine. - 1741-7015. ; 21:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: A dysregulated postprandial metabolic response is a risk factor for chronic diseases, including type 2 diabetes mellitus (T2DM). The plasma protein N-glycome is implicated in both lipid metabolism and T2DM risk. Hence, we first investigate the relationship between the N-glycome and postprandial metabolism and then explore the mediatory role of the plasma N-glycome in the relationship between postprandial lipaemia and T2DM. Methods: We included 995 individuals from the ZOE-PREDICT 1 study with plasma N-glycans measured by ultra-performance liquid chromatography at fasting and triglyceride, insulin, and glucose levels measured at fasting and following a mixed-meal challenge. Linear mixed models were used to investigate the associations between plasma protein N-glycosylation and metabolic response (fasting, postprandial (C max), or change from fasting). A mediation analysis was used to further explore the relationship of the N-glycome in the prediabetes (HbA1c = 39–47 mmol/mol (5.7–6.5%))–postprandial lipaemia association. Results: We identified 36 out of 55 glycans significantly associated with postprandial triglycerides (C max β ranging from -0.28 for low-branched glycans to 0.30 for GP26) after adjusting for covariates and multiple testing (p adjusted < 0.05). N-glycome composition explained 12.6% of the variance in postprandial triglycerides not already explained by traditional risk factors. Twenty-seven glycans were also associated with postprandial glucose and 12 with postprandial insulin. Additionally, 3 of the postprandial triglyceride–associated glycans (GP9, GP11, and GP32) also correlate with prediabetes and partially mediate the relationship between prediabetes and postprandial triglycerides. Conclusions: This study provides a comprehensive overview of the interconnections between plasma protein N-glycosylation and postprandial responses, demonstrating the incremental predictive benefit of N-glycans. We also suggest a considerable proportion of the effect of prediabetes on postprandial triglycerides is mediated by some plasma N-glycans.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Metabolic response
- Plasma N-glycome
- Postprandial glycaemia
- Postprandial lipaemia
- Protein glycosylation
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Louca, Panayioti ...
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Štambuk, Tamara
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Frkatović-Hodžić ...
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Nogal, Ana
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Mangino, Massimo
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Berry, Sarah E.
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visa fler...
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Deriš, Helena
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Hadjigeorgiou, G ...
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Wolf, Jonathan
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Vinicki, Martina
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Franks, Paul W.
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Valdes, Ana M.
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Spector, Tim D.
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Lauc, Gordan
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Menni, Cristina
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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BMC Medicine
- Av lärosätet
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Lunds universitet