Sökning: onr:"swepub:oai:lup.lub.lu.se:7f5f670b-0e25-4290-a470-9850ba25dc9a" >
Novel ABCA1 peptide...
Novel ABCA1 peptide agonists with antidiabetic action
-
- Azhar, Salman (författare)
- Stanford University
-
- Bittner, Stefanie (författare)
- VA Palo Alto Health Care System
-
- Hu, Jie (författare)
- VA Palo Alto Health Care System
-
visa fler...
-
- Shen, Wen Jun (författare)
- Stanford University
-
- Cortez, Yuan (författare)
- VA Palo Alto Health Care System
-
- Hao, Xiao (författare)
- Stanford University,First Affiliated Hospital of Zhengzhou University
-
- Han, Lu (författare)
- VA Palo Alto Health Care System
-
- Lagerstedt, Jens O. (författare)
- Lund University,Lunds universitet,Medicinsk proteinvetenskap,Forskargrupper vid Lunds universitet,Medical Protein Science,Lund University Research Groups
-
- Kraemer, Fredric B. (författare)
- Stanford University
-
- Johansson, Jan O. (författare)
- Artery Therapeutics Inc.
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
-
Ingår i: Molecular and Cellular Endocrinology. - : Elsevier BV. - 0303-7207. ; 480, s. 1-11
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://europepmc.or...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Previously, apoE-derived ABCA1 agonist peptides have been shown to possess anti-atherosclerotic and possibly antidiabetic properties. Here we assessed the in vitro and in vivo actions of a second generation of ABCA1 peptide agonists, CS6253 and T6991-2, on glucose homeostasis. The results show that these two peptides improve glucose tolerance in a prediabetic diet-induced obesity mouse model by enhancing insulin secretion. It was further demonstrated that T6991-2 also improved glucose tolerance in leptin-deficient (ob/ob) mice. CS6253 increased insulin secretion both under basal conditions and in response to high glucose stimulation in pancreatic INS-1 β-cells rendered leptin receptor deficient with specific siRNA. Additional in vitro cell studies suggest that the CS6253 agonist attenuates hepatic gluconeogenesis and glucose transport. It also potentiates insulin-stimulated glucose uptake and utilization. These observed anti-diabetic actions suggest additional benefits of the CS6253 and T6991-2 ABCA1 peptide agonists for cardiovascular disease beyond their direct anti-atherosclerosis properties previously described.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Atherosclerosis
- Diet induced diabetes
- Glucose homeostasis
- HDL mimetic
- Insulin secretagogue
- Type 2 diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Azhar, Salman
-
Bittner, Stefani ...
-
Hu, Jie
-
Shen, Wen Jun
-
Cortez, Yuan
-
Hao, Xiao
-
visa fler...
-
Han, Lu
-
Lagerstedt, Jens ...
-
Kraemer, Fredric ...
-
Johansson, Jan O ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Molecular and Ce ...
- Av lärosätet
-
Lunds universitet