Sökning: onr:"swepub:oai:lup.lub.lu.se:7f8b80d5-2a68-4e70-9234-c6d343d6c4f6" >
Review and perspect...
Review and perspectives on the structure–function relationships of the gag subunits of feline immunodeficiency virus
-
- Long, Mathieu (författare)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,University of Lyon
-
- Toesca, Johan (författare)
- Claude Bernard University Lyon 1,University of Lyon
-
- Guillon, Christophe (författare)
- University of Lyon
-
(creator_code:org_t)
- 2021-11-18
- 2021
- Engelska.
-
Ingår i: Pathogens. - : MDPI AG. - 2076-0817. ; 10:11
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://www.mdpi.com...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- The Gag polyprotein is implied in the budding as well as the establishment of the supramolecular architecture of infectious retroviral particles. It is also involved in the early phases of the replication of retroviruses by protecting and transporting the viral genome towards the nucleus of the infected cell until its integration in the host genome. Therefore, understanding the structure– function relationships of the Gag subunits is crucial as each of them can represent a therapeutic target. Though the field has been explored for some time in the area of Human Immunodeficiency Virus (HIV), it is only in the last decade that structural data on Feline Immunodeficiency Virus (FIV) Gag subunits have emerged. As FIV is an important veterinary issue, both in domestic cats and endangered feline species, such data are of prime importance for the development of anti-FIV molecules targeting Gag. This review will focus on the recent advances and perspectives on the structure–function relationships of each subunit of the FIV Gag polyprotein.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Capsid
- Feline Immunodeficiency Virus
- FIV
- Gag
- HIV
- Human Immunodeficiency Virus
- Late domain
- Matrix
- Nucleocapsid
- Structure
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas