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Tau pathology media...
Tau pathology mediates age effects on medial temporal lobe structure
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- Wisse, Laura EM (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Xie, Long (författare)
- University of Pennsylvania
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- Das, Sandhitsu R. (författare)
- University of Pennsylvania
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- de Flores, Robin (författare)
- University of Caen Normandy
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Habes, Mohamad (författare)
- University of Texas Health Science Centre
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- Doshi, Jimit (författare)
- University of Pennsylvania
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- Davatzikos, Christos (författare)
- University of Pennsylvania
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- Yushkevich, Paul A. (författare)
- University of Pennsylvania
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- Wolk, David A. (författare)
- University of Pennsylvania
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(creator_code:org_t)
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- Elsevier BV, 2022
- 2022
- Engelska 10 s.
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Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 109, s. 135-144
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Hippocampal atrophy is endemic in ‘normal aging’ but it is unclear what factors drive age-related changes in medial temporal lobe (MTL) structural measures. We investigated cross-sectional (n = 191) and longitudinal (n = 164) MTL atrophy patterns in cognitively normal older adults from ADNI-GO/2 with no to low cerebral β-amyloid and assessed whether white matter hyperintensities (WMHs) and cerebrospinal fluid (CSF) phospho tau (p-tau) levels can explain age-related changes in the MTL. Age was significantly associated with hippocampal volumes and Brodmann Area (BA) 35 thickness, regions affected early by neurofibrillary tangle pathology, in the cross-sectional analysis and with anterior and/or posterior hippocampus, entorhinal cortex and BA35 in the longitudinal analysis. CSF p-tau was significantly associated with hippocampal volumes and atrophy rates. Mediation analyses showed that CSF p-tau levels partially mediated age effects on hippocampal atrophy rates. No significant associations were observed for WMHs. These findings point toward a role of tau pathology, potentially reflecting Primary Age-Related Tauopathy, in age-related MTL structural changes and suggests a potential role for tau-targeted interventions in age-associated neurodegeneration and memory decline.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Aging
- Longitudinal
- Medial temporal lobe
- Phospho-tau
- Primary age-related tauopathy
- White matter hyperintensities
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Wisse, Laura EM
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Xie, Long
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Das, Sandhitsu R ...
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de Flores, Robin
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Hansson, Oskar
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Habes, Mohamad
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visa fler...
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Doshi, Jimit
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Davatzikos, Chri ...
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Yushkevich, Paul ...
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Wolk, David A.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Neurobiology of ...
- Av lärosätet
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Lunds universitet