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Local Flip Angle Co...
Local Flip Angle Correction for Improved Volume T1-Quantification in Three-Dimensional dGEMRIC Using the Look-Locker Technique
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- Siversson, Carl (författare)
- Lund University,Lunds universitet,Enheten för led- och mjukvävnadsforskning,Forskargrupper vid Lunds universitet,Medicinsk strålningsfysik, Malmö,Joint and Soft Tissue Unit,Lund University Research Groups,Medical Radiation Physics, Malmö
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- Tiderius, Carl Johan (författare)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Enheten för led- och mjukvävnadsforskning,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Joint and Soft Tissue Unit
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- Dahlberg, Leif (författare)
- Lund University,Lunds universitet,Enheten för led- och mjukvävnadsforskning,Forskargrupper vid Lunds universitet,Joint and Soft Tissue Unit,Lund University Research Groups
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- Svensson, Jonas (författare)
- Lund University,Lunds universitet,Enheten för led- och mjukvävnadsforskning,Forskargrupper vid Lunds universitet,Medicinsk strålningsfysik, Malmö,Joint and Soft Tissue Unit,Lund University Research Groups,Medical Radiation Physics, Malmö
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(creator_code:org_t)
- Wiley, 2009
- 2009
- Engelska.
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Ingår i: Journal of Magnetic Resonance Imaging. - : Wiley. - 1522-2586 .- 1053-1807. ; 30:4, s. 834-841
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- Purpose: To present an evaluation method for three-dimensional Look-Locker (3D-LL) based T1 quantification, calculating correct T1 values independent of local flip angle (FA) variations. The method was evaluated both in phantoms and in vivo in a delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) study with 33 subjects. Materials and Methods: T1 was measured with 3D-LL, using both local FA correction and a precalculated FA slice profile. and compared with standard constant FA correction, for all slices in phantoms and in both femur condyles in vivo. T1 measured using two-dimensional Inversion Recovery (2D-IR) was used as gold standard. Results: Due to the FA being slice dependent, the standard constant FA correction results in erroneous T1 (systematic error = 109.1 ms in vivo), especially in the outer slices. With local FA correction. the calculated T1 is excellent for all slices in phantoms (<5% deviation from 2D-IR). In vivo the performance is lower (systematic error = -57.5ms), probably due to imperfect inversion. With precalculated FA correction the performance is very good also in vivo (systematic error = 13.3 ms). Conclusion: With the precalculated FA correction method, the 3D-LL sequence is robust enough for in vivo dGEMRIC, even outside the centermost slices.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- dGEMRIC
- B1 correction
- flip angle correction
- Look-Locker
- T1 mapping
- cartilage
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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