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CRP, C-Peptide, and...
CRP, C-Peptide, and Risk of First-Time Cardiovascular Events and Mortality in Early Type 2 Diabetes : A Danish Cohort Study
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- Gedebjerg, Anne (författare)
- Aarhus University Hospital
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- Bjerre, Mette (författare)
- Aarhus University
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- Kjaergaard, Alisa Devedzic (författare)
- Aarhus University Hospital
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- Nielsen, Jens Steen (författare)
- Odense University Hospital
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- Rungby, Jørgen (författare)
- Bispebjerg Hospital,Steno Diabetes Center Copenhagen
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- Brandslund, Ivan (författare)
- Vejle Hospital
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- Maeng, Michael (författare)
- Aarhus University Hospital
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- Beck-Nielsen, Henning (författare)
- Odense University Hospital
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- Vaag, Allan (författare)
- Lund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Steno Diabetes Center Copenhagen
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- Sørensen, Henrik Toft (författare)
- Aarhus University Hospital
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- Hansen, Troels Krarup (författare)
- Aarhus University Hospital
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- Thomsen, Reimar Wernich (författare)
- Aarhus University Hospital
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(creator_code:org_t)
- 2023-03-17
- 2023
- Engelska 9 s.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 46:5, s. 1037-1045
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- We investigated the relationship between hs-CRP, a marker of low-grade inflam-mation, alone or in combination with C-peptide, a marker of hyperinsulinemia/ insulin resistance, and risk for cardiovascular events (CVEs) and mortality in patients recently diagnosed with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In patients with recent-onset T2D, we measured serum hs-CRP (n = 7,301) and C-peptide (n = 5,765) in the prospective Danish Centre for Strategic Research in Type 2 Diabetes cohort study. Patients with no prior CVE (n = 6,407) were followed until first myocardial infarction, stroke, coronary revascularization, or cardiovascular death, and all patients (n = 7,301) were followed for all-cause mortality. We com-puted adjusted hazard ratios (aHRs) by Cox regression and tested for the interaction between hs-CRP and C-peptide. RESULTS During follow-up (median 4.8 years), high (>3 mg/L) versus low (<1 mg/L) hs-CRP was associated with increased CVE risk (aHR 1.45 [95% CI 1.07–1.96]) and with even greater risk of all-cause mortality (2.47 [1.88–3.25]). Compared with patients with low hs-CRP (£3 mg/L) and low C-peptide (<1,470 pmol/L), those with high lev-els of both biomarkers had the highest CVE (1.61 [1.10–2.34]) and all-cause mortality risk (2.36 [1.73–3.21]). Among patients with high C-peptide, risk of CVEs did not differ by low or high hs-CRP, whereas risk of all-cause mortality did. CONCLUSIONS The finding of high hs-CRP as a stronger prognostic biomarker of all-cause mortality than of CVEs may facilitate improved early detection and prevention of deadly diseases besides CVEs. Conversely, elevated C-peptide as a strong CVE biomarker sup-ports the need to target hyperinsulinemia/insulin resistance in T2D CVE prevention.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Av författaren/redakt...
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Gedebjerg, Anne
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Bjerre, Mette
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Kjaergaard, Alis ...
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Nielsen, Jens St ...
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Rungby, Jørgen
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Brandslund, Ivan
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visa fler...
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Maeng, Michael
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Beck-Nielsen, He ...
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Vaag, Allan
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Sørensen, Henrik ...
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Hansen, Troels K ...
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Thomsen, Reimar ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes Care
- Av lärosätet
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Lunds universitet