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Metagenomics of the...
Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children : The TEDDY study
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- Lindfors, Katri (författare)
- University of Tampere
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- Lin, Jake (författare)
- University of Tampere,University of Helsinki
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- Lee, Hye Seung (författare)
- University of South Florida
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- Hyöty, Heikki (författare)
- University of Tampere
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- Nykter, Matti (författare)
- University of Tampere
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- Kurppa, Kalle (författare)
- Tampere University Hospital,University of Tampere
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- Liu, Edwin (författare)
- University of Colorado,The Children's Hospital, Aurora
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- Koletzko, Sibylle (författare)
- Dr. von Haunersches Kinderspital,Ludwig-Maximilian University of Munich
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- Rewers, Marian (författare)
- University of Colorado
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- Hagopian, William (författare)
- Pacific Northwest Research Institute
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- Toppari, Jorma (författare)
- University of Turku,Turku University Hospital
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- Ziegler, Annette Gabriele (författare)
- Klinikum rechts der Isar,Helmholtz Zentrum München
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- Akolkar, Beena (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Krischer, Jeffrey P. (författare)
- University of South Florida
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- Petrosino, Joseph F. (författare)
- Baylor College of Medicine
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- Lloyd, Richard E. (författare)
- Baylor College of Medicine
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- Agardh, Daniel (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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(creator_code:org_t)
- 2019-11-19
- 2020
- Engelska 7 s.
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Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 69:8, s. 1416-1422
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://gut.bmj.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Higher gluten intake, frequent gastrointestinal infections and adenovirus, enterovirus, rotavirus and reovirus have been proposed as environmental triggers for coeliac disease. However, it is not known whether an interaction exists between the ingested gluten amount and viral exposures in the development of coeliac disease. This study investigated whether distinct viral exposures alone or together with gluten increase the risk of coeliac disease autoimmunity (CDA) in genetically predisposed children. Design: The Environmental Determinants of Diabetes in the Young study prospectively followed children carrying the HLA risk haplotypes DQ2 and/or DQ8 and constructed a nested case-control design. From this design, 83 CDA case-control pairs were identified. Median age of CDA was 31 months. Stool samples collected monthly up to the age of 2 years were analysed for virome composition by Illumina next-generation sequencing followed by comprehensive computational virus profiling. Results: The cumulative number of stool enteroviral exposures between 1 and 2 years of age was associated with an increased risk for CDA. In addition, there was a significant interaction between cumulative stool enteroviral exposures and gluten consumption. The risk conferred by stool enteroviruses was increased in cases reporting higher gluten intake. Conclusions: Frequent exposure to enterovirus between 1 and 2 years of age was associated with increased risk of CDA. The increased risk conferred by the interaction between enteroviruses and higher gluten intake indicate a cumulative effect of these factors in the development of CDA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- coeliac disease
- gluten
- small bowel
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Lindfors, Katri
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Lin, Jake
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Lee, Hye Seung
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Hyöty, Heikki
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Nykter, Matti
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Kurppa, Kalle
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visa fler...
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Liu, Edwin
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Koletzko, Sibyll ...
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Rewers, Marian
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Hagopian, Willia ...
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Toppari, Jorma
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Ziegler, Annette ...
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Akolkar, Beena
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Krischer, Jeffre ...
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Petrosino, Josep ...
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Lloyd, Richard E ...
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Agardh, Daniel
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