SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:8302de9a-1079-4608-93bb-3ab6b685698b"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:8302de9a-1079-4608-93bb-3ab6b685698b" > Vitamin D deficienc...

  • Pincikova, T.Karolinska Institutet (författare)

Vitamin D deficiency as a risk factor for cystic fibrosis-related diabetes in the Scandinavian Cystic Fibrosis Nutritional Study

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • 2011-09-07
  • Springer Science and Business Media LLC,2011

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:8302de9a-1079-4608-93bb-3ab6b685698b
  • https://lup.lub.lu.se/record/2291919URI
  • https://doi.org/10.1007/s00125-011-2287-1DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-164837URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123669502URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Aims/hypothesis Many cystic fibrosis patients are vitamin D-insufficient. Cystic fibrosis-related diabetes is a major complication of cystic fibrosis. The literature suggests that vitamin D might possess certain glucose-lowering properties. We aimed to assess the relationship between vitamin D and cystic fibrosis-related glucose intolerance. Methods We enrolled 898 cystic fibrosis patients from Sweden, Norway and Denmark. Vitamin D intake was assessed using a seven-day food record. Serum 25-hydroxyvitamin D (s25OHD) and HbA(1c) were measured, and an OGTT was carried out. Multiple linear and logistic regressions were used for HbA(1c) and cystic fibrosis-related diabetes/OGTT result as outcome variables, respectively. Each model was controlled for country, and for known cystic fibrosis-related diabetes risk factors: age, sex, genotype, liver dysfunction, long-term corticosteroid treatment, and lung and pancreatic function. Results Degree of vitamin D insufficiency (OR 1.36; p=0.032) and s25OHD<30 nmol/l (OR 1.79; p=0.042) were significant risk factors for cystic fibrosis-related diabetes. Accordingly, HbA(1c) value was positively associated with s25OHD<30 nmol/l and<50 nmol/l, as well as with degree of vitamin D insufficiency (adjusted R-2=20.5% and p<0.05 in all). In subgroup analyses, s25OHD<30 nmol/l determined the HbA(1c) value in paediatric patients (adjusted R-2=20.2%; p=0.017), but not in adults. Conclusions/interpretation Vitamin D status is associated with HbA(1c) and diabetes in cystic fibrosis, particularly in children. The study justifies prospective studies on the proposed role of vitamin D deficiency in the pathophysiology of diabetes mellitus.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Nilsson, K.Stockholm CF Centre, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden (författare)
  • Moen, I. E.National Centre for Cystic Fibrosis, University Hospital Ullevaal, Oslo, Norway (författare)
  • Fluge, G.Cystic Fibrosis Centre, Department of Paediatrics, Haukeland University Hospital, Bergen, Norway (författare)
  • Hollsing, Annika,1949-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall(Swepub:uu)annho840 (författare)
  • Knudsen, P. K.National Centre for Cystic Fibrosis, University Hospital Ullevaal, Oslo, Norway (författare)
  • Lindblad, A.The West Swedish CF Centre, Sahlgrenska University Hospital, Gothenburg, Sweden (författare)
  • Mared, LenaLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung Centre, Lund University Hospital, Lund, Sweden(Swepub:lu)lung-lma (författare)
  • Pressler, T.Cystic Fibrosis Centre, Department of Paediatrics, Copenhagen University Hospital, Denmark (författare)
  • Hjelte, L.Karolinska Institutet (författare)
  • Karolinska InstitutetStockholm CF Centre, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetologia: Springer Science and Business Media LLC54:12, s. 3007-30151432-04280012-186X

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy