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Sökning: onr:"swepub:oai:lup.lub.lu.se:8308e68a-d8a1-4b37-8838-bb18e83a0cb3" > Subclinical atheros...

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FältnamnIndikatorerMetadata
00005250naa a2200577 4500
001oai:lup.lub.lu.se:8308e68a-d8a1-4b37-8838-bb18e83a0cb3
003SwePub
008181113s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:140045723
009oai:gup.ub.gu.se/273776
0247 a https://lup.lub.lu.se/record/8308e68a-d8a1-4b37-8838-bb18e83a0cb32 URI
0247 a https://doi.org/10.1016/j.ijcard.2018.08.1042 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1400457232 URI
0247 a https://gup.ub.gu.se/publication/2737762 URI
040 a (SwePub)lud (SwePub)kid (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Tarp, Julie Bjerreu University of Copenhagen4 aut
2451 0a Subclinical atherosclerosis in patients with cyanotic congenital heart disease
264 1b Elsevier BV,c 2019
520 a Introduction: Survival in patients with cyanotic congenital heart disease (CCHD) has improved dramatically. The result is an ageing population with risk of acquired heart disease. Previous small uncontrolled studies suggested that these patients are protected against the development of atherosclerosis. To test this hypothesis, we sought to determine the prevalence of subclinical atherosclerosis in a larger population of patients with CCHD. Method: We compared the prevalence of subclinical atherosclerosis in adult CCHD patients from Denmark, Sweden, Norway and Australia, with that in age-, sex-, smoking status-, and body mass index matched controls. Coronary artery atherosclerosis was assessed on computed tomography with coronary artery calcification (CAC) score. Subclinical atherosclerosis was defined by CAC-score > 0. Carotid artery atherosclerosis was evaluated using ultrasound by measuring carotid plaque thickness (cPT-max) and carotid intima media thickness (CIMT). Lipid status was evaluated as an important atherosclerotic risk factor. Results: Seventy-four patients with CCHD (57% women, median age 49.5 years) and 74 matched controls (57% women, median age 50.0 years) were included. There were no differences between the groups in: CAC-score > 0 (21% vs. 19%, respectively; p = 0.8), carotid plaques (19% vs. 9%, respectively; p = 0.1), cPT-max (2.3 mm vs. 2.8 mm, respectively; p = 0.1) or CIMT (0.61 mm vs. 0.61 mm, respectively; p = 0.98). And further no significant differences in lipoprotein concentrations measured by ultracentrifugation. Conclusion: Young adults with CCHD have similar cardiovascular risk factor profiles and measures of subclinical atherosclerosis, compared with controls. Given their increasing life expectancies, athero-preventive strategies should be an important part of their clinical management.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Cardiovascular disease
653 a Carotid artery atherosclerosis
653 a Coronary artery atherosclerosis
653 a Coronary artery calcification
653 a Cyanotic congenital heart disease
653 a Hyperlipidemia
7001 a Sørgaard, Mathias Holmu University of Copenhagen4 aut
7001 a Christoffersen, Christinau University of Copenhagen,Copenhagen University Hospital4 aut
7001 a Jensen, Annette Schophuusu University of Copenhagen4 aut
7001 a Sillesen, Henriku University of Copenhagen4 aut
7001 a Celermajer, Davidu Royal Prince Alfred Hospital4 aut
7001 a Eriksson, Peter J,d 1959u Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xerpet
7001 a Estensen, Mette Eliseu Norwegian Radium Hospital4 aut
7001 a Nagy, Editu Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Holstein-Rathlou, Niels Henriku University of Copenhagen4 aut
7001 a Engstrøm, Thomasu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Copenhagen4 aut0 (Swepub:lu)th4331en
7001 a Søndergaard, Larsu University of Copenhagen4 aut
7102 a University of Copenhagenb Copenhagen University Hospital4 org
7730 t International Journal of Cardiologyd : Elsevier BVg 277, s. 97-103q 277<97-103x 0167-5273x 1874-1754
8564 u http://dx.doi.org/10.1016/j.ijcard.2018.08.104y FULLTEXT
8564 8u https://lup.lub.lu.se/record/8308e68a-d8a1-4b37-8838-bb18e83a0cb3
8564 8u https://doi.org/10.1016/j.ijcard.2018.08.104
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140045723
8564 8u https://gup.ub.gu.se/publication/273776

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