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Tyrosyl radicals in...
Tyrosyl radicals in enzyme catalysis: Some properties and a focus on photosynthetic water oxidation
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Babcock, Gerald T (författare)
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Espe, M (författare)
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Hoganson, Curtis (författare)
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LydakisSimantiris, N (författare)
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McCracken, Vance J (författare)
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Shi, W J (författare)
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- Styring, Stenbjörn (författare)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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Tommos, Cecilia (författare)
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Warncke, K (författare)
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: Acta Chemica Scandinavica. - 0904-213X. ; 51:5, s. 533-540
- Relaterad länk:
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http://www.ncbi.nlm....
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Enzymes that require a redox-active amino acid for catalysis or function have emerged as a distinct class of proteins. For the tyrosine-based radical enzymes, we show that the spin-density distribution in the radical follows an odd alternate pattern that is invariant to within 10% across the class. General properties of the radical enzymes are summarized from which we conclude that their essential role in catalysis is to initiate substrate metabolism by hydrogen-atom abstraction. These ideas are extended to the Y-Z and Y-D tyrosines in Photosystem II and a radical-based hydrogen-atom abstraction model for water oxidation is discussed. Differences in rates of oxidation of Y-Z and Y-D by the reaction-center chlorophyll, P680(+), under various conditions, are considered and rationalized on the basis of changes in reorganization energy induced by the local protein structure and by the presence or absence of the (Mn)(4) cluster that binds substrate water.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- HYDROGEN HYPERFINE INTERACTIONS
- ELECTRON-TRANSFER REACTIONS
- SITE-DIRECTED MUTANTS
- PHOTOSYSTEM-II
- RIBONUCLEOTIDE REDUCTASE
- RESONANCE SPECTROSCOPIES
- VIBRATIONAL FREQUENCIES
- SPIN-DENSITIES
- Y-Z
- TYROSINE(D)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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