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Causality assessmen...
Causality assessment of circulating Vitamin D level on venous thromboembolism : A Mendelian randomization study
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- Zhang, Xiaoyu (författare)
- Sanbo Brain Hospital Capital Medical University
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- Sun, Wen (författare)
- Capital University of Medical Sciences
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- Li, Ning (författare)
- Capital University of Medical Sciences
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- Jian, Xuening (författare)
- Capital University of Medical Sciences
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Geng, Tao (författare)
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- Wu, Lijuan (författare)
- Capital University of Medical Sciences
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- Wang, Youxin (författare)
- Edith Cowan University,Capital University of Medical Sciences
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- Wang, Baoguo (författare)
- Sanbo Brain Hospital Capital Medical University
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- Zheng, Deqiang (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Capital University of Medical Sciences
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(creator_code:org_t)
- 2023
- 2023
- Engelska 8 s.
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Ingår i: Nutrition, Metabolism and Cardiovascular Diseases. - 0939-4753. ; 33:9, s. 1800-1807
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background and aims: The associations of vitamin D level with venous thromboembolism (VTE) reported in observational studies, whereas these causal associations were uncertain in European population. Therefore, we used Mendelian randomization (MR) method to explore the causal associations between 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of VTE and its subtypes [including deep vein thrombosis (DVT) and pulmonary embolism (PE)]. Methods and results: We used three kinds of genetic instruments to proxy the exposure of 25(OH)D, including genetic variants significantly associated with 25(OH)D, expression quantitative trait loci of 25(OH)D target genes, and genetic variants within or nearby 25(OH)D target genes. MR analyses did not provide any evidence for the associations of 25(OH)D levels with VTE and its subtypes (p > 0.05). The summary-data-based MR (SMR) analyses indicated that elevated expression of VDR was associated with decreased risk of VTE (OR = 0.81; 95% CI, 0.65–0.998; p = 0.047) and PE (OR = 0.67; 95% CI, 0.50–0.91; p = 0.011), and expression of AMDHD1 was associated with PE (OR = 0.93; 95% CI, 0.88–0.99; p = 0.027). MR analysis provided a significant causal effect of 25(OH)D level mediated by gene AMDHD1 on PE risk (OR = 0.09; 95% CI, 0.01–0.60; p = 0.012). Conclusion: Our MR analysis did not support causal association of 25(OH)D level with the risk of VTE and its subtypes. In addition, the expression of VDR and AMDHD1 involved in vitamin D metabolism showed a strong association with VTE or PE and might represent targets for these conditions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Causality
- eQTLs
- Mendelian randomization
- Venous thromboembolism
- Vitamin D
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zhang, Xiaoyu
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Sun, Wen
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Li, Ning
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Jian, Xuening
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Geng, Tao
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Wu, Lijuan
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Wang, Youxin
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Wang, Baoguo
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Zheng, Deqiang
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
- Artiklar i publikationen
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Nutrition, Metab ...
- Av lärosätet
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Lunds universitet