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Sökning: onr:"swepub:oai:lup.lub.lu.se:862454a2-461a-45f6-8a1e-cb03155c30b2" > Liver blood dynamic...

  • Honka, HenriUniversity of Turku (författare)

Liver blood dynamics after bariatric surgery : The effects of mixed-meal test and incretin infusions

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018
  • 9 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:862454a2-461a-45f6-8a1e-cb03155c30b2
  • https://lup.lub.lu.se/record/862454a2-461a-45f6-8a1e-cb03155c30b2URI
  • https://doi.org/10.1530/EC-18-0234DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Aims/hypothesis: The mechanisms for improved glycemic control after bariatric surgery in subjects with type 2 diabetes (T2D) are not fully known. We hypothesized that dynamic hepatic blood responses to a mixed-meal are changed after bariatric surgery in parallel with an improvement in glucose tolerance. Methods: A total of ten morbidly obese subjects with T2D were recruited to receive a mixed-meal and a glucose-dependent insulinotropic polypeptide (GIP) infusion before and early after (within a median of less than three months) bariatric surgery, and hepatic blood flow and volume (HBV) were measured repeatedly with combined positron emission tomography/MRI. Ten lean non-diabetic individuals served as controls. Results: Bariatric surgery leads to a significant decrease in weight, accompanied with an improved β-cell function and glucagon-like peptide 1 (GLP-1) secretion, and a reduction in liver volume. Blood flow in portal vein (PV) was increased by 1.65-fold (P = 0.026) in response to a mixed-meal in subjects after surgery, while HBV decreased in all groups (P < 0.001). When the effect of GIP infusion was tested separately, no change in hepatic arterial and PV flow was observed, but HBV decreased as seen during the mixed-meal test. Conclusions/interpretation: Early after bariatric surgery, PV flow response to a mixed-meal is augmented, improving digestion and nutrient absorption. GIP influences the post-prandial reduction in HBV thereby diverting blood to the extrahepatic sites.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Koffert, JukkaUniversity of Turku,Turku University Hospital (författare)
  • Kauhanen, SailaTurku University Hospital (författare)
  • Kudomi, NobuyukiKagawa University (författare)
  • Hurme, SaijaUniversity of Turku (författare)
  • Mari, AndreaCNR Institute of Neuroscience, Pisa (författare)
  • Lindqvist, AndreasLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups(Swepub:lu)medk-alt (författare)
  • Wierup, NilsLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups(Swepub:lu)mphy-nwi (författare)
  • Parkkola, RiittaTurku University Hospital,University of Turku (författare)
  • Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (författare)
  • Nuutila, PirjoUniversity of Turku,Turku University Hospital (författare)
  • University of TurkuTurku University Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Endocrine Connections7:7, s. 888-8962049-3614

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