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Atypical Anti-Glome...
Atypical Anti-Glomerular Basement Membrane Nephritis : A Case Series From the French Nephropathology Group
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- Chauveau, Bertrand (författare)
- Centre Hospitalier Universitaire de Bordeaux
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- Gibier, Jean-Baptiste (författare)
- Novosibirsk Research Institute of Circulation Pathology Academician EN Meshalkina (NNIIPK)
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- Olagne, Jérôme (författare)
- University Hospital Of Strasbourg
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- Morel, Antoine (författare)
- Henri Mondor Hospital
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- Aydin, Selda (författare)
- Catholic University of Louvain
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- McAdoo, Stephen P (författare)
- Imperial College London
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Viallet, Nicolas (författare)
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Perrochia, Hélène (författare)
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- Pambrun, Emilie (författare)
- CHU Nîmes
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Royal, Virginie (författare)
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Demoulin, Nathalie (författare)
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- Kemeny, Jean-Louis (författare)
- Clermont-Ferrand University Hospital
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- Philipponnet, Carole (författare)
- Clermont-Ferrand University Hospital
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Hertig, Alexandre (författare)
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- Boffa, Jean-Jacques (författare)
- Wake Forest University
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- Plaisier, Emmanuelle (författare)
- Wake Forest University
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Domenger, Camille (författare)
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Brochériou, Isabelle (författare)
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- Deltombe, Clément (författare)
- Nantes University Hospital
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Duong Van Huyen, Jean-Paul (författare)
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- Buob, David (författare)
- Pitié-Salpêtrière University Hospital
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- Roufosse, Candice (författare)
- Imperial College London
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- Hellmark, Thomas (författare)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Autoimmunitet och njursjukdomar,Forskargrupper vid Lunds universitet,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Autoimmunity and kidney diseases,Lund University Research Groups
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- Audard, Vincent (författare)
- Henri Mondor Hospital
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- Mihout, Fabrice (författare)
- Wake Forest University
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- Nasr, Samih H (författare)
- Indiana University
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- Renaudin, Karine (författare)
- Nantes University Hospital
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- Moktefi, Anissa (författare)
- University Paris-Est Créteil
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- Rabant, Marion (författare)
- Université Paris Cité
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(creator_code:org_t)
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- Engelska.
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Ingår i: American Journal of Kidney Diseases. - 1523-6838.
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- RATIONALE & OBJECTIVE: Atypical anti-glomerular basement membrane (GBM) nephritis is characterized by a bright linear immunoglobulin staining along the GBM by immunofluorescence without a diffuse crescentic glomerulonephritis nor serum anti-GBM antibodies by conventional ELISA. We characterized a series of patients with atypical anti-GBM disease.STUDY DESIGN: Case series.SETTING & PARTICIPANTS: Patients were identified by the French Nephropathology Group as having atypical anti-GBM nephritis between 2003 and 2022.FINDINGS: Among 38 potential cases, 25 were included. 14 (56%) were female and 23 (92%) had hematuria. Median [interquartile range (IQR)] serum creatinine at diagnosis was 150 [102-203] μmol/L and median [IQR] urine protein to creatinine ratio was 2.4 [1.3-5.2] g/g. 9 (36%) patients had endocapillary proliferative glomerulonephritis (GN), 4 (16%) had mesangial proliferative GN, 4 (16%) had membranoproliferative GN, 2 (8%) had pure and focal crescentic GN, 1 (4%) had focal segmental glomerulosclerosis, and 5 had glomeruli that were unremarkable on histopathology. Nine patients (36%) had crescents, involving a median of 9% of glomeruli. Bright linear staining for IgG was seen in 22 cases (88%) and for IgA in 3 cases (12%). The nine patients (38%) who had a monotypic staining pattern tended to be older with less proteinuria and rarely had crescents. Kidney survival rate at one year was 83% and did not appear to be associated with the light chain restriction.LIMITATIONS: Retrospective case series with a limited number of biopsies including electron microscopy.CONCLUSIONS: Compared to typical anti-GBM disease, atypical anti-GBM nephritis frequently presents with endocapillary or mesangial proliferative glomerulonephritis pattern and appears to have slower disease progression. Further studies are needed to fully characterize its pathophysiology and associated clinical outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Chauveau, Bertra ...
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Gibier, Jean-Bap ...
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Olagne, Jérôme
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Morel, Antoine
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Aydin, Selda
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McAdoo, Stephen ...
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visa fler...
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Viallet, Nicolas
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Perrochia, Hélèn ...
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Pambrun, Emilie
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Royal, Virginie
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Demoulin, Nathal ...
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Kemeny, Jean-Lou ...
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Philipponnet, Ca ...
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Hertig, Alexandr ...
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Boffa, Jean-Jacq ...
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Plaisier, Emmanu ...
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Domenger, Camill ...
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Brochériou, Isab ...
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Deltombe, Clémen ...
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Duong Van Huyen, ...
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Buob, David
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Roufosse, Candic ...
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Hellmark, Thomas
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Audard, Vincent
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Mihout, Fabrice
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Nasr, Samih H
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Renaudin, Karine
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Moktefi, Anissa
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Rabant, Marion
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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American Journal ...
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Lunds universitet