onr:"swepub:oai:lup.lub.lu.se:8793bb0b-94c1-47f1-adcb-3a28b03f33f8"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04382naa a2200433 4500 | |
| 001 | oai:lup.lub.lu.se:8793bb0b-94c1-47f1-adcb-3a28b03f33f8 | |
| 003 | SwePub | |
| 008 | 160401s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/6066232 URI |
| 024 | 7 | a https://doi.org/10.1253/circj.71.14802 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Liuba, Petruu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pedi-pli |
| 245 | 1 0 | a Effects of Bradykinin on Aortic Endothelial Function in ApoE-Knockout Mice With Chronic Chlamydia Pneumoniae Infection. |
| 264 | 1 | b Japanese Circulation Society,c 2007 |
| 520 | a Background Impaired muscarinic receptor-mediated vasodilation is an important feature of early atherosclerosis. Earlier studies on apolipoprotein E-knockout mice (apoE-KO) mice suggested adverse effects of Chlamydia pneumoniae infection on the endothelial vasomotor responses of aortas to the muscarinic agonist methacholine. Using additional aorta samples the present study investigated the responses to bradykinin. Methods and Results ApoE-KO mice were repeatedly inoculated with either Chlamydia pneumoniae (C. pneumoniae) or saline. At 2, 6, and 10 weeks after the first inoculation, precontracted aorta rings from both groups were exposed to bradykinin in the absence and presence of L-NAME and diclofenac. In noninfected animals, the vasomotor responses to bradykinin were similar at all timepoints (p > 0.5). Compared with noninfected animals, the responses in infected animals tended to increase through the study period (p < 0.05 at 10 weeks). Although diclofenac and L-NAME had no effect in noninfected mice, they inhibited the responses to bradykinin in infected mice at 6 and, more markedly, 10 weeks (p < 0.05 for both). Conclusion Bradykinin stimulation of aorta endothelium from C. pneumoniae-infected apoE-KO animals appears to activate compensatory kinin receptor-related mechanisms that could involve nitric oxide and vasorelaxing prostanoids. Although the precise molecular mechanisms require further investigation, one could speculate that strategies increasing bradykinin availability might reverse the arterial dysfunction during chronic infectious disease. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 653 | a infection | |
| 653 | a relaxation | |
| 653 | a bradykinin | |
| 653 | a endothelium | |
| 700 | 1 | a Karnani, Päivi4 aut |
| 700 | 1 | a Pesonen, Erkkiu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pedi-epe |
| 700 | 1 | a Paakkari, Ilari4 aut |
| 700 | 1 | a Persson, Kennethu Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-kpe |
| 700 | 1 | a Forslid, Andersu Lund University,Lunds universitet,Universitetsveterinären,Medicinska fakulteten,University Veterinary,Faculty of Medicine4 aut0 (Swepub:lu)fde-afo |
| 710 | 2 | a Pediatrik, Lundb Sektion V4 org |
| 773 | 0 | t Circulation Journald : Japanese Circulation Societyg 71:9, s. 1480-1484q 71:9<1480-1484x 1346-9843x 1347-4820 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17721032&dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1253/circj.71.1480y FULLTEXT |
| 856 | 4 | u https://www.jstage.jst.go.jp/article/circj/71/9/71_9_1480/_pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/606623 |
| 856 | 4 8 | u https://doi.org/10.1253/circj.71.1480 |
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