Sökning: onr:"swepub:oai:lup.lub.lu.se:8922b8c5-3ca7-459b-b559-d5765325b777" > Diffusion tensor MR...
Fältnamn | Indikatorer | Metadata |
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000 | 05857naa a2200469 4500 | |
001 | oai:lup.lub.lu.se:8922b8c5-3ca7-459b-b559-d5765325b777 | |
003 | SwePub | |
008 | 191216s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/8922b8c5-3ca7-459b-b559-d5765325b7772 URI |
024 | 7 | a https://doi.org/10.1148/radiol.20191904062 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Spotorno, Nicolau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University of Pennsylvania4 aut0 (Swepub:lu)ni1407sp |
245 | 1 0 | a Diffusion tensor MRI to distinguish progressive supranuclear palsy from a-synucleinopathies |
264 | 1 | b Radiological Society of North America (RSNA),c 2019 |
300 | a 8 s. | |
520 | a Background: The differential diagnosis of progressive supranuclear palsy (PSP) and Lewy body disorders, which include Parkinson disease and dementia with Lewy bodies, is often challenging due to the overlapping symptoms. Purpose: To develop a diagnostic tool based on diffusion tensor imaging (DTI) to distinguish between PSP and Lewy body disorders at the individual-subject level. Materials and Methods: In this retrospective study, skeletonized DTI metrics were extracted from two independent data sets: the discovery cohort from the Swedish BioFINDER study and the validation cohort from the Penn Frontotemporal Degeneration Center (data collected between 2010 and 2018). Based on previous neuroimaging studies and neuropathologic evidence, a combination of regions hypothesized to be sensitive to pathologic features of PSP were identified (ie, the superior cerebellar peduncle and frontal white matter) and fractional anisotropy (FA) was used to compute an FA score for each individual. Classification performances were assessed by using logistic regression and receiver operating characteristic analysis. Results: In the discovery cohort, 16 patients with PSP (mean age 6 standard deviation, 73 years 6 5; eight women, eight men), 34 patients with Lewy body disorders (mean age, 71 years 6 6; 14 women, 20 men), and 44 healthy control participants (mean age, 66 years 6 8; 26 women, 18 men) were evaluated. The FA score distinguished between clinical PSP and Lewy body disorders with an area under the curve of 0.97 6 0.04, a specificity of 91% (31 of 34), and a sensitivity of 94% (15 of 16). In the validation cohort, 34 patients with PSP (69 years 6 7; 22 women, 12 men), 25 patients with Lewy body disorders (70 years 6 7; nine women, 16 men), and 32 healthy control participants (64 years 6 7; 22 women, 10 men) were evaluated. The accuracy of the FA score was confirmed (area under the curve, 0.96 6 0.04; specificity, 96% [24 of 25]; and sensitivity, 85% [29 of 34]). Conclusion: These cross-validated findings lay the foundation for a clinical test to distinguish progressive supranuclear palsy from Lewy body disorders. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
700 | 1 | a Hall, Sarau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-sha |
700 | 1 | a Irwin, David J.u University of Pennsylvania4 aut |
700 | 1 | a Rumetshofer, Theodoru Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)th6284ru |
700 | 1 | a Acosta-Cabronero, Juliou University College London4 aut |
700 | 1 | a Deik, Andres F.u University of Pennsylvania4 aut |
700 | 1 | a Spindler, Meredith A.u University of Pennsylvania4 aut |
700 | 1 | a Lee, Edward B.u University of Pennsylvania4 aut |
700 | 1 | a Trojanowski, John Q.u University of Pennsylvania4 aut |
700 | 1 | a Van Westen, Danielleu Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups4 aut0 (Swepub:lu)ront-dva |
700 | 1 | a Nilsson, Markusu Lund University,Lunds universitet,Neuroradiologi,Forskargrupper vid Lunds universitet,Neuroradiology,Lund University Research Groups4 aut0 (Swepub:lu)med-mun |
700 | 1 | a Grossman, Murrayu University of Pennsylvania4 aut |
700 | 1 | a Nestor, Peter J.u University of Queensland4 aut |
700 | 1 | a McMillan, Corey T.u University of Pennsylvania4 aut |
700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn |
710 | 2 | a Klinisk minnesforskningb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Radiologyd : Radiological Society of North America (RSNA)g 293:3, s. 646-653q 293:3<646-653x 0033-8419x 1527-1315 |
856 | 4 | u http://dx.doi.org/10.1148/radiol.2019190406y FULLTEXT |
856 | 4 | u https://pubs.rsna.org/doi/pdf/10.1148/radiol.2019190406 |
856 | 4 8 | u https://lup.lub.lu.se/record/8922b8c5-3ca7-459b-b559-d5765325b777 |
856 | 4 8 | u https://doi.org/10.1148/radiol.2019190406 |
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