Sökning: onr:"swepub:oai:lup.lub.lu.se:89e7e833-58d5-46b2-812c-8eae45990842" >
Association Between...
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Koulaouzidis, AnastasiosRoyal Infirmary of Edinburgh
(författare)
Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy : A Multicenter Retrospective Study
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-03-23
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Springer Science and Business Media LLC,2016
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:89e7e833-58d5-46b2-812c-8eae45990842
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https://lup.lub.lu.se/record/89e7e833-58d5-46b2-812c-8eae45990842URI
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https://doi.org/10.1007/s10620-016-4104-7DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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BACKGROUND: Accurate inflammation reporting in capsule endoscopy (CE) is important for diagnosis and monitoring of treatment of inflammatory bowel disease (IBD). Fecal calprotectin (FC) is a highly specific biomarker of gut inflammation. Lewis score (LS) was developed to standardize quantification of inflammation in small-bowel (SB) CE images.GOALS: Multicenter retrospective study aiming to investigate correlation between LS and FC in a large group of patients undergoing CE for suspected or known small-bowel IBD, and to develop a model for prediction of CE results (LS) based on FC levels.STUDY: Five academic centers and a district general hospital offering CE in UK, Finland, Sweden, Canada, and Israel. In total, 333 patients were recruited. They had small-bowel CE and FC done within 3 months.RESULTS: Overall, correlation between FC and LS was weak (r s: 0.232, P < 0.001). When two clinically significant FC thresholds (100 and 250 μg/g) were examined, the r s between FC and LS was 0.247 (weak) and 0.337 (moderate), respectively (P = 0.307). For clinically significant (LS ≥ 135) or negative (LS < 135) for SB inflammation, ROC curves gave an optimum cutoff point of FC 76 μg/g with sensitivity 0.59 and specificity 0.41.LIMITATIONS: Retrospective design.CONCLUSIONS: LS appears to show low correlation with FC as well as other serology markers of inflammation. FC does not appear to be a reliable biomarker for significant small-bowel inflammation. Nevertheless, FC level ≥ 76 μg/g may be associated with appreciable visual inflammation on small-bowel CE in patients with negative prior diagnostic workup.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sipponen, TainaUniversity of Helsinki
(författare)
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Nemeth, ArturLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups(Swepub:lu)med-aun
(författare)
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Makins, RichardGloucestershire Hospitals NHS Foundation Trust
(författare)
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Kopylov, UriMcGill University
(författare)
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Nadler, MosheTel-Aviv University
(författare)
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Giannakou, AndryOpen University of Cyprus
(författare)
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Yung, Diana ERoyal Infirmary of Edinburgh
(författare)
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Johansson, Gabriele WurmLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups(Swepub:lu)med-giw
(författare)
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Bartzis, LeonidasRoyal Infirmary of Edinburgh
(författare)
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Thorlacius, HenrikLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)kir-hth
(författare)
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Seidman, Ernest GMcGill University
(författare)
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Eliakim, RamiTel-Aviv University
(författare)
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Plevris, John NRoyal Infirmary of Edinburgh
(författare)
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Toth, ErvinLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups(Swepub:lu)ront-eto
(författare)
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Royal Infirmary of EdinburghUniversity of Helsinki
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Digestive Diseases and Sciences: Springer Science and Business Media LLC61:7, s. 2033-20401573-25680163-2116
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Koulaouzidis, An ...
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Sipponen, Taina
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Nemeth, Artur
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Makins, Richard
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Kopylov, Uri
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Nadler, Moshe
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Giannakou, Andry
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Yung, Diana E
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Johansson, Gabri ...
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Bartzis, Leonida ...
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Thorlacius, Henr ...
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Seidman, Ernest ...
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Eliakim, Rami
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Plevris, John N
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Toth, Ervin
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