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T regulatory cells ...
T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10
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- Kapur, Rick (författare)
- Canadian Blood Services,Saint Michael's Hospital
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- Kim, Michael (författare)
- Saint Michael's Hospital
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- Aslam, Rukhsana (författare)
- Saint Michael's Hospital
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- McVey, Mark J (författare)
- Saint Michael's Hospital
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- Tabuchi, Arata (författare)
- University of Toronto
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- Luo, Alice (författare)
- University of Toronto
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- Liu, Jonathan (författare)
- Saint Michael's Hospital
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- Li, Yuan (författare)
- Shandong University
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- Shanmugabhavananthan, Shanjeevan (författare)
- Saint Michael's Hospital
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- Speck, Edwin R (författare)
- Saint Michael's Hospital
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- Zufferey, Anne (författare)
- Saint Michael's Hospital
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Yousef, George (författare)
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Zhang, Haibo (författare)
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Rondina, Matthew T (författare)
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Weyrich, Andrew S (författare)
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Porcelijn, Leendert (författare)
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Kuebler, Wolfgang M (författare)
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Slutsky, Arthur S (författare)
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- Semple, John W (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Saint Michael's Hospital,Canadian Blood Services,University of Toronto
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(creator_code:org_t)
- American Society of Hematology, 2017
- 2017
- Engelska 13 s.
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 129:18, s. 2557-2569
- Relaterad länk:
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http://dx.doi.org/10...
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https://ashpublicati...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by acute respiratory distress following blood transfusion. Donor antibodies are frequently involved; however, the pathogenesis and protective mechanisms in the recipient are poorly understood, and specific therapies are lacking. Using newly developed murine TRALI models based on injection of anti-major histocompatibility complex class I antibodies, we found CD4+CD25+FoxP3+ T regulatory cells (Tregs) and CD11c+ dendritic cells (DCs) to be critical effectors that protect against TRALI. Treg or DC depletion in vivo resulted in aggravated antibody-mediated acute lung injury within 90 minutes with 60% mortality upon DC depletion. In addition, resistance to antibody-mediated TRALI was associated with increased interleukin-10 (IL-10) levels, and IL-10 levels were found to be decreased in mice suffering from TRALI. Importantly, IL-10 injection completely prevented and rescued the development of TRALI in mice and may prove to be a promising new therapeutic approach for alleviating lung injury in this serious complication of transfusion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Acute Lung Injury
- Animals
- Antibodies
- Dendritic Cells
- Interleukin-10
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- T-Lymphocytes, Regulatory
- Transfusion Reaction
- Journal Article
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
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Blood
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Till lärosätets databas
- Av författaren/redakt...
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Kapur, Rick
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Kim, Michael
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Aslam, Rukhsana
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McVey, Mark J
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Tabuchi, Arata
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Luo, Alice
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visa fler...
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Liu, Jonathan
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Li, Yuan
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Shanmugabhavanan ...
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Speck, Edwin R
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Zufferey, Anne
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Yousef, George
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Zhang, Haibo
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Rondina, Matthew ...
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Weyrich, Andrew ...
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Porcelijn, Leend ...
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Kuebler, Wolfgan ...
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Slutsky, Arthur ...
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Semple, John W
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Immunologi inom ...
- Artiklar i publikationen
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Blood
- Av lärosätet
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Lunds universitet