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Pathological driver...
Pathological drivers of neurodegeneration in suspected non-Alzheimer’s disease pathophysiology
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- Wisse, L. E.M. (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Pennsylvania
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- de Flores, R. (författare)
- University of Caen Normandy
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- Xie, L. (författare)
- University of Pennsylvania
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- Das, S. R. (författare)
- University of Pennsylvania
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- McMillan, C. T. (författare)
- University of Pennsylvania
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- Trojanowski, J. Q. (författare)
- University of Pennsylvania
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- Grossman, M. (författare)
- University of Pennsylvania
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- Lee, E. B. (författare)
- University of Pennsylvania
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- Irwin, D. (författare)
- University of Pennsylvania
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- Yushkevich, P. A. (författare)
- University of Pennsylvania
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- Wolk, D. A. (författare)
- University of Pennsylvania
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(creator_code:org_t)
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- 2021-05-14
- 2021
- Engelska.
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Ingår i: Alzheimer's Research and Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 13
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://alzres.biome...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Little is known about the heterogeneous etiology of suspected non-Alzheimer’s pathophysiology (SNAP), a group of subjects with neurodegeneration in the absence of β-amyloid. Using antemortem MRI and pathological data, we investigated the etiology of SNAP and the association of neurodegenerative pathologies with structural medial temporal lobe (MTL) measures in β-amyloid-negative subjects. Methods: Subjects with antemortem MRI and autopsy data were selected from ADNI (n=63) and the University of Pennsylvania (n=156). Pathological diagnoses and semi-quantitative scores of MTL tau, neuritic plaques, α-synuclein, and TDP-43 pathology and MTL structural MRI measures from antemortem T1-weighted MRI scans were obtained. β-amyloid status (A+/A−) was determined by CERAD score and neurodegeneration status (N+/N−) by hippocampal volume. Results: SNAP reflects a heterogeneous group of pathological diagnoses. In ADNI, SNAP (A−N+) had significantly more neuropathological diagnoses than A+N+. In the A− group, tau pathology was associated with hippocampal, entorhinal cortex, and Brodmann area 35 volume/thickness and TDP-43 pathology with hippocampal volume. Conclusion: SNAP had a heterogeneous profile with more mixed pathologies than A+N+. Moreover, a role for TDP-43 and tau pathology in driving MTL neurodegeneration in the absence of β-amyloid was supported.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Hippocampus
- Limbic-predominant age-related TDP-43 encephalopathy
- Medial temporal lobe
- Neurodegeneration
- Neurodegenerative pathologies
- Neuropathologies diagnosis
- Primary age-related tauopathy
- Suspected non-Alzheimer’s pathophysiology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wisse, L. E.M.
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de Flores, R.
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Xie, L.
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Das, S. R.
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McMillan, C. T.
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Trojanowski, J. ...
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visa fler...
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Grossman, M.
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Lee, E. B.
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Irwin, D.
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Yushkevich, P. A ...
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Wolk, D. A.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Alzheimer's Rese ...
- Av lärosätet
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Lunds universitet