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Sökning: onr:"swepub:oai:lup.lub.lu.se:8b8d491f-57c8-4a4d-8b68-93f00f14173e" > CSF ferritin in the...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004801naa a2200421 4500
001oai:lup.lub.lu.se:8b8d491f-57c8-4a4d-8b68-93f00f14173e
003SwePub
008230120s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/8b8d491f-57c8-4a4d-8b68-93f00f14173e2 URI
0247 a https://doi.org/10.1136/jnnp-2022-3300522 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ayton, Scottu University of Melbourne,The Florey Institute of Neuroscience and Mental Health4 aut
2451 0a CSF ferritin in the clinicopathological progression of Alzheimer's disease and associations with APOE and inflammation biomarkers
264 c 2022-11-10
264 1b BMJ,c 2023
520 a Background: A putative role for iron in driving Alzheimer's disease (AD) progression is complicated by previously reported associations with neuroinflammation, apolipoprotein E and AD proteinopathy. To establish how iron interacts with clinicopathological features of AD and at what disease stage iron influences cognitive outcomes, we investigated the association of cerebrospinal fluid (CSF) biomarkers of iron (ferritin), inflammation (acute phase response proteins) and apolipoproteins with pathological biomarkers (CSF Aβ42/t-tau, p-tau181), clinical staging and longitudinal cognitive deterioration in subjects from the BioFINDER cohort, with replication of key results in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Methods: Ferritin, acute phase response proteins (n=9) and apolipoproteins (n=6) were measured in CSF samples from BioFINDER (n=1239; 4 years cognitive follow-up) participants stratified by cognitive status (cognitively unimpaired, mild cognitive impairment, AD) and for the presence of amyloid and tangle pathology using CSF Aβ42/t-tau (A+) and p-tau181 (T+). The ferritin and apolipoprotein E associations were replicated in the ADNI (n=264) cohort. Results: In both cohorts, ferritin and apoE were elevated in A-T+ and A+T+ subjects (16%-40%), but not clinical diagnosis. Other apolipoproteins and acute phase response proteins increased with clinical diagnosis, not pathology. CSF ferritin was positively associated with p-tau181, which was mediated by apolipoprotein E. An optimised threshold of ferritin predicted cognitive deterioration in mild cognitive impairment subjects in the BioFINDER cohort, especially those people classified as A-T- and A+T-. Conclusions: CSF markers of iron and neuroinflammation have distinct associations with disease stages, while iron may be more intimately associated with apolipoprotein E and tau pathology.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a alzheimer's disease
653 a iron deposition
7001 a Janelidze, Shorenau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)nkir-sje
7001 a Kalinowski, Pawelu University of Melbourne,The Florey Institute of Neuroscience and Mental Health4 aut
7001 a Palmqvist, Sebastianu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-spa
7001 a Belaidi, Abdel Aliu The Florey Institute of Neuroscience and Mental Health,University of Melbourne4 aut
7001 a Stomrud, Eriku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-esr
7001 a Roberts, Anneu Emory University4 aut
7001 a Roberts, Blaineu Emory University4 aut
7001 a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)mphy-ohn
7001 a Bush, Ashley Ianu The Florey Institute of Neuroscience and Mental Health,University of Melbourne4 aut
7102 a University of Melbourneb The Florey Institute of Neuroscience and Mental Health4 org
7730 t Journal of Neurology, Neurosurgery and Psychiatryd : BMJg 94:3, s. 211-219q 94:3<211-219x 0022-3050x 1468-330X
8564 u http://dx.doi.org/10.1136/jnnp-2022-330052y FULLTEXT
8564 8u https://lup.lub.lu.se/record/8b8d491f-57c8-4a4d-8b68-93f00f14173e
8564 8u https://doi.org/10.1136/jnnp-2022-330052

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