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Metabolite profilin...
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Al-Majdoub, MahmoudLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
(författare)
Metabolite profiling of LADA challenges the view of a metabolically distinct subtype
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2016-12-02
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American Diabetes Association,2017
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9 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:8bff9d7f-8842-4c0a-b558-e28eb5f9351c
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https://lup.lub.lu.se/record/8bff9d7f-8842-4c0a-b558-e28eb5f9351cURI
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https://doi.org/10.2337/db16-0779DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)-positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA fromtype 1 or type 2 diabetes. In this study, we examined whether metabolite profiling could help to distinguish LADA (n = 50) from type 1 diabetes (n = 50) and type 2 diabetes (n = 50). Of 123 identified metabolites, 99 differed between the diabetes types. However, no unique metabolite profile could be identified for any of the types. Instead, the metabolome varied along a C-peptide-driven continuum from type 1 diabetes via LADA to type 2 diabetes. LADA was more similar to type 2 diabetes than to type 1 diabetes. In a principal component analysis, LADA patients overlapping with type 1 diabetes progressed faster to insulin therapy than those overlapping with type 2 diabetes. In conclusion, we could not find any unique metabolite profile distinguishing LADA from type 1 and type 2 diabetes. Rather, LADA was metabolically an intermediate of type 1 and type 2 diabetes, with those patients closer to the former showing a faster progression to insulin therapy than those closer to the latter.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ali, ArslanUniversity of Karachi
(författare)
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Storm, PetterLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Translational Muscle Research,Lund University Research Groups(Swepub:lu)med-psm
(författare)
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Rosengren, Anders H.Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups(Swepub:lu)mphy-aro
(författare)
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Groop, LeifLund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM)(Swepub:lu)endo-lgr
(författare)
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Spégel, PeterLund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)tekn-psp
(författare)
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Diabetes - molekylär metabolismForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes: American Diabetes Association66:4, s. 806-8140012-17971939-327X
Internetlänk
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Diabetes
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