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Low birthweight in ...
Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality
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- Hansen, Aleksander L. (författare)
- Aarhus University Hospital,Steno Diabetes Center Copenhagen
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- Brøns, Charlotte (författare)
- Steno Diabetes Center Copenhagen
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- Engelhard, Leonie M. (författare)
- Lund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Aarhus University Hospital,Steno Diabetes Center Copenhagen
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- Andersen, Mette K. (författare)
- Novo Nordisk Foundation Centre for Basic Metabolic Research
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- Hansen, Torben (författare)
- Novo Nordisk Foundation Centre for Basic Metabolic Research
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- Nielsen, Jens S. (författare)
- Odense University Hospital
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- Vestergaard, Peter (författare)
- Aalborg University Hospital
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- Højlund, Kurt (författare)
- Odense University Hospital
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- Jessen, Niels (författare)
- Aarhus University Hospital
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- Olsen, Michael H. (författare)
- University of Copenhagen,Holbæk Hospital
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- Sørensen, Henrik T. (författare)
- Aarhus University Hospital
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- Thomsen, Reimar W. (författare)
- Aarhus University Hospital
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- Vaag, Allan (författare)
- Lund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Skåne University Hospital,Steno Diabetes Center Copenhagen
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(creator_code:org_t)
- Engelska.
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Ingår i: Diabetologia. - 0012-186X.
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes and CVD. This prospective cohort study investigated whether lower birthweight increases CVD risk after diagnosis of type 2 diabetes. Methods: Original midwife records were evaluated for 8417 participants recently diagnosed with type 2 diabetes in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Patients were followed for the first occurrence of a composite CVD endpoint (myocardial infarction, coronary revascularisation, peripheral arterial disease, stroke, unstable angina, heart failure or CVD death), a three-component endpoint comprising major adverse cardiovascular events (MACE), and all-cause mortality. Ten-year risks were estimated using the Aalen–Johansen estimator considering non-CVD death as a competing risk. HRs were determined by Cox regression. Models were controlled for sex, age, calendar year at birth, family history of diabetes and born-at-term status. Results: A total of 1187 composite CVD endpoints, 931 MACE, and 1094 deaths occurred during a median follow-up period of 8.5 years. The 10-year standardised composite CVD risk was 19.8% in participants with a birthweight <3000 g compared with 16.9% in participants with a birthweight of 3000–3700 g, yielding a risk difference (RD) of 2.9% (95% CI 0.4, 5.4) and an adjusted HR of 1.20 (95% CI 1.03, 1.40). The 10-year MACE risk for birthweight <3000 g was similarly elevated (RD 2.4%; 95% CI 0.1, 4.7; HR 1.22; 95% CI 1.01, 1.46). The elevated CVD risk was primarily driven by stroke, peripheral arterial disease and CVD death. All-cause mortality showed no substantial difference. Conclusions/interpretation: Having a birthweight <3000 g is associated with higher CVD risk among patients with type 2 diabetes, driven primarily by risk of stroke and CVD death. Graphical Abstract: (Figure presented.)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Birthweight
- Cardiovascular disease
- Cohort study
- Epidemiology
- Fetal programming
- Mortality
- Stroke
- Type 2 diabetes
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Till lärosätets databas
- Av författaren/redakt...
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Hansen, Aleksand ...
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Brøns, Charlotte
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Engelhard, Leoni ...
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Andersen, Mette ...
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Hansen, Torben
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Nielsen, Jens S.
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Vestergaard, Pet ...
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Højlund, Kurt
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Jessen, Niels
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Olsen, Michael H ...
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Sørensen, Henrik ...
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Thomsen, Reimar ...
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Vaag, Allan
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Diabetologia
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Lunds universitet