Variations in the practice of molecular radiotherapy and implementation of dosimetry : results from a European survey

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Variations in the practice of molecular radiotherapy and implementation of dosimetry : results from a European survey

Sjögreen Gleisner, Katarina (författare): Lund University,Lunds universitet,Nuclear Medicine Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Dept Med Radiat Phys, Clin Sci Lund, Lund, Sweden.

Spezi, Emiliano (författare): Cardiff University,Cardiff Univ, Sch Engn, Cardiff, S Glam, Wales.

Solny, Pavel (författare): University Hospital Motol,Charles Univ Prague, Motol Univ Hosp, Dept Nucl Med & Endocrinol, Fac Med 2, Prague, Czech Republic.

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Gabina, Pablo Minguez (författare): Gurutzeta/Cruces University Hospital,Gurutzeta Cruces Univ Hosp, Dept Med Phys & Radiat Protect, Baracaldo, Spain.

Cicone, Francesco (författare): Sapienza University of Rome,Sapienza Univ Rome, Dept Surg & Med Sci & Translat Med, St Andrea Hosp, Nucl Med, Rome, Italy.

Stokke, Caroline (författare): Oslo university hospital,Oslo Univ Hosp, Dept Diagnost Phys, Oslo, Norway.

Chiesa, Carlo (författare): Istituto Nazionale dei Tumori,Fdn IRCCS Ist Nazl Tumori, Div Nucl Med, Milan, Italy.

Paphiti, Maria (författare): Pammakaristos Hospital,Pammakaristos Hosp, Dept Med Phys, Athens, Greece.

Brans, Boudewijn (författare): Ghent University Hospital,Univ Hosp, Dept Nucl Med, Ghent, Belgium.;Univ Hosp, PET Ctr, Ghent, Belgium.

Sandström, Mattias (författare): Uppsala universitet,Radiologi

Tipping, Jill (författare): Christie NHS Foundation Trust,Christie NHS Fdn Trust, Nucl Med, Manchester, Lancs, England.

Konijnenberg, Mark (författare): Erasmus University Medical Center,Erasmus MC, Dept Nucl Med, Rotterdam, Netherlands.

Flux, Glenn (författare): Institute of Cancer Research London,Royal Marsden Hosp, Dept Phys, Sutton, Surrey, England.;Inst Canc Res, Sutton, Surrey, England.

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2017-12-04
2017
Engelska.
Ingår i: EJNMMI Physics. - : Springer Science and Business Media LLC. - 2197-7364. ; 4:1

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Background: Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availability of dosimetry-based MRT in clinical practice and research studies. The aim of this study was to assess the current practice of MRT and dosimetry across European countries. Methods: An electronic questionnaire was distributed to European countries. This addressed 18 explicitly considered therapies, and for each therapy, a similar set of questions were included. Questions covered the number of patients and treatments during 2015, involvement of medical specialties and medical physicists, implementation of absorbed dose planning, post-therapy imaging and dosimetry, and the basis of therapy prescription. Results: Responses were obtained from 26 countries and 208 hospitals, administering in total 42,853 treatments. The most common therapies were 131I-NaI for benign thyroid diseases and thyroid ablation of adults. The involvement of a medical physicist (mean over all 18 therapies) was reported to be either minority or never by 32% of the responders. The percentage of responders that reported that dosimetry was included on an always/majority basis differed between the therapies and showed a median value of 36%. The highest percentages were obtained for 177Lu-PSMA therapy (100%), 90Y microspheres of glass (84%) and resin (82%), 131I-mIBG for neuroblastoma (59%), and 131I-NaI for benign thyroid diseases (54%). The majority of therapies were prescribed based on fixed-activity protocols. The highest number of absorbed-dose based prescriptions were reported for 90Y microsphere treatments in the liver (64% and 96% of responses for resin and glass, respectively), 131I-NaI treatment of benign thyroid diseases (38% of responses), and for 131I-mIBG treatment of neuroblastoma (18% of responses). Conclusions: There is a wide variation in MRT practice across Europe and for different therapies, including the extent of medical-physicist involvement and the implementation of dosimetry-guided treatments.

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Av författaren/redakt...: Sjögreen Gleisne ...; Spezi, Emiliano; Solny, Pavel; Gabina, Pablo Mi ...; Cicone, Francesc ...; Stokke, Caroline; visa fler...; Chiesa, Carlo; Paphiti, Maria; Brans, Boudewijn; Sandström, Matti ...; Tipping, Jill; Konijnenberg, Ma ...; Flux, Glenn; visa färre...

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Variations in the practice of molecular radiotherapy and implementation of dosimetry : results from a European survey

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