Sökning: onr:"swepub:oai:lup.lub.lu.se:8df4d8ce-c8de-4ff8-b188-f72e9807a163" >
Activation of type ...
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Bengtsson, AndersLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
(författare)
Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
- Artikel/kapitelEngelska2000
Förlag, utgivningsår, omfång ...
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2016-07-02
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SAGE Publications,2000
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:8df4d8ce-c8de-4ff8-b188-f72e9807a163
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https://lup.lub.lu.se/record/1117344URI
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https://doi.org/10.1191/096120300674499064DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in serial sera from 30 patients sampled at different stages of disease activity (SLEDAI score). The SLE-IIF activity was measured by its ability to induce IFN-alpha production in cultures of normal peripheral blood mononuclear cells. Both serum IFN-alpha and SLE-IIF increased markedly at flare in serially followed patients. The SLEDAI score, levels of anti-dsDNA antibodies and IL-10 correlated positively, and complement components Clq, C3 and leukocytes correlated inversely with serum concentrations of IFN-alpha. The extent of multiple organ involvement correlated with serum IFN-alpha. No relation between concentrations of retroviral peptide binding antibodies and IFN-alpha or SLE-IIF activity was found. The close relationship between disease activity in SLE patients and IFN-alpha serum levels suggests that activation of the type 1 IFN system might be of importance in the disease process.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-gst
(författare)
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Truedsson, LennartLund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-ltr
(författare)
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Blomberg, J
(författare)
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Alm, G
(författare)
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Vallin, H
(författare)
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Ronnblom, L
(författare)
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Reumatologi och molekylär skelettbiologiSektion III
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Lupus: SAGE Publications9:9, s. 664-6710961-20331477-0962
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