Sökning: onr:"swepub:oai:lup.lub.lu.se:8ed32a6e-0388-406f-8a45-0adb98ef011f" >
T cells that are na...
T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis
-
Malmstrom, Vivianne (författare)
-
- Bäcklund, Johan (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
-
- Jansson, Liselotte (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
-
visa fler...
-
- Kihlberg, J (författare)
- Umeå universitet,Kemiska institutionen
-
- Holmdahl, Rikard (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
-
visa färre...
-
(creator_code:org_t)
- Springer Science and Business Media LLC, 2000
- 2000
- Engelska.
-
Ingår i: Arthritis Research. - : Springer Science and Business Media LLC. - 1465-9905. ; 2:4, s. 315-326
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://arthritis-re...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 256-270 epitope in cartilage, the CII-specific T cells are characterized by a partially tolerant state with low proliferative activity in vitro, but with maintained effector functions, such as IFN-gamma secretion and ability to provide B cell help. These mice were still susceptible to CIA. The response was mainly directed to the glycosylated form of the CII 256-270 peptide, rather than to the nonglycosylated peptide. Tolerance induction was rapid; transferred T cells encountered CII within a few days. CII immunization several weeks after thymectomy of the mice did not change their susceptibility to arthritis or the induction of partial T-cell tolerance, excluding a role for recent thymic emigrants. Thus, partially tolerant CII autoreactive T cells are maintained and are crucial for the development of CIA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- autoimmunity
- rheumatoid arthritis
- T lymphocytes
- tolerance
- transgenic
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas