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Rapid genetic analy...
Rapid genetic analysis in congenital hyperinsulinism
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Christesen, Henrik B. T. (författare)
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Brusgaard, Klaus (författare)
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Alm, Jan (författare)
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- Sjöblad, Sture (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Hussain, Khalid (författare)
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Fenger, Claus (författare)
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Rasmussen, Lars (författare)
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Hovendal, Claus (författare)
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Otonkoski, Timo (författare)
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Jacobsen, Bendt Brock (författare)
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(creator_code:org_t)
- 2006-11-15
- 2007
- Engelska.
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Ingår i: Hormone Research. - : S. Karger AG. - 0301-0163. ; 67:4, s. 184-188
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Backgound: In severe, medically unresponsive congenital hyperinsulinism (CHI), the histological differentiation of focal versus diffuse disease is vital, since the surgical management is completely different. Genetic analysis may help in the differential diagnosis, as focal CHI is associated with a paternal germline ABCC8 or KCNJ11 mutation and a focal loss of maternal chromosome 11p15, whereas a maternal mutation, or homozygous/compound heterozygous ABCC8 and KCNJ11 mutations predict diffuse-type disease. However, genotyping usually takes too long to be helpful in the absence of a founder mutation. Methods: In 4 patients, a rapid genetic analysis of the ABBC8 and KCNJ11 genes was performed within 2 weeks on request prior to the decision of pancreatic surgery. Results: Two patients had no mutations, rendering the genetic analysis non-informative. Peroperative multiple biopsies showed diffuse disease. One patient had a paternal KCNJ11 mutation and focal disease confirmed by positron emission tomography scan and biopsies. One patient had a de novo heterozygous ABBC8 mutation and unexplained diffuse disease confirmed by positron emission tomography scan and biopsies. Conclusion: A rapid analysis of the entire ABBC8 and KCNJ11 genes should not stand alone in the preoperative assessment of patients with CHI, except for the case of maternal, or homozygous/compound heterozygous disease-causing mutations. Copyright (c) 2007 S. Karger AG, Basel.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- hyperinsulinaemic hypoglycaemia
- genotype-phenotype correlation
- beta-cell
- congenital hyperinsulinism
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Christesen, Henr ...
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Brusgaard, Klaus
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Alm, Jan
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Sjöblad, Sture
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Hussain, Khalid
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Fenger, Claus
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visa fler...
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Rasmussen, Lars
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Hovendal, Claus
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Otonkoski, Timo
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Jacobsen, Bendt ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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Hormone Research
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Hormone Research ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet