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Sökning: onr:"swepub:oai:lup.lub.lu.se:8ee4455e-30c9-4ed5-b985-fd248c7f5cbb" > Human Leukocyte Ant...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00010346naa a2201021 4500
001oai:lup.lub.lu.se:8ee4455e-30c9-4ed5-b985-fd248c7f5cbb
003SwePub
008240320s2024 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:153972347
009oai:DiVA.org:liu-198977
0247 a https://lup.lub.lu.se/record/8ee4455e-30c9-4ed5-b985-fd248c7f5cbb2 URI
0247 a https://doi.org/10.1093/ecco-jcc/jjad1652 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1539723472 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1989772 URI
040 a (SwePub)lud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Zheng, Tenghaou Karolinska Institute,Monash University,Monash Univ, Australia; Karolinska Inst, Sweden4 aut
2451 0a Human Leukocyte Antigen Signatures as Pathophysiological Discriminants of Microscopic Colitis Subtypes
264 1b OXFORD UNIV PRESS,c 2024
300 a 11 s.
500 a Funding Agencies|Swedish Research Council [VR 2017-02403]
520 a Background and Aims: Microscopic colitis [MC] is currently regarded as an inflammatory bowel disease that manifests as two subtypes: collagenous colitis [CC] and lymphocytic colitis [LC]. Whether these represent a clinical continuum or distinct entities is, however, an open question. Genetic investigations may contribute important insight into their respective pathophysiologies. Methods: We conducted a genome-wide association study [GWAS] meta-analysis in 1498 CC, 373 LC patients, and 13 487 controls from Europe and the USA, combined with publicly available MC GWAS data from UK Biobank and FinnGen [2599 MC cases and 552 343 controls in total]. Human leukocyte antigen [HLA] alleles and polymorphic residues were imputed and tested for association, including conditional analyses for the identification of key causative variants and residues. Genetic correlations with other traits and diagnoses were also studied. Results: We detected strong HLA association with CC, and conditional analyses highlighted the DRB1*03:01 allele and its residues Y26, N77, and R74 as key to this association (best p = 1.4 × 10-23, odds ratio [OR] = 1.96). Nominally significant genetic correlations were detected between CC and pneumonia [rg = 0.77; p = 0.048] and oesophageal diseases [rg = 0.45, p = 0.023]. An additional locus was identified in MC GWAS analyses near the CLEC16A and RMI2 genes on chromosome 16 [rs35099084, p = 2.0 × 10-8, OR = 1.31]. No significant association was detected for LC. Conclusion: Our results suggest CC and LC have distinct pathophysiological underpinnings, characterised by an HLA predisposing role only in CC. This challenges existing classifications, eventually calling for a re-evaluation of the utility of MC umbrella definitions.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653 a collagenous colitis
653 a genetics
653 a GWAS
653 a HLA
653 a Microscopic colitis
653 a Microscopic colitis; collagenous colitis; GWAS; HLA; genetics
7001 a Roda, Giuliau National Institute Of Biostructures And Biosystems,Biostruct & Biosyst Natl Inst, Italy4 aut
7001 a Zabana, Yamileu CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd),Mutua De Terrassa Hospital,Hosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain4 aut
7001 a Escudero-Hernández, Celiau Linköpings universitet,Linköping University,University of Kiel,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Univ Kiel, Germany; Univ Med Ctr Schleswig Holstein, Germany4 aut0 (Swepub:liu)celes93
7001 a Liu, Xingrongu Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden4 aut
7001 a Chen, Yeu Massachusetts General Hospital,Massachusetts Gen Hosp, MA USA4 aut
7001 a Tavares, Leticia Camargou Monash University,Monash Univ, Australia4 aut
7001 a Bonfiglio, Ferdinandou Karolinska Institute,Monash University,Monash Univ, Australia; Karolinska Inst, Sweden4 aut
7001 a Mellander, Marie Roseu Skåne University Hospital,Lund Univ, Sweden4 aut
7001 a Janczewska, Izabellau Ersta Hospital,Ersta Hosp, Sweden4 aut
7001 a Vigren, Linau Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)med-lvi
7001 a Sjöberg, Klasu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,LTH profilområde: Avancerade ljuskällor,LTH profilområden,Lunds Tekniska Högskola,LU profilområde: Ljus och material,Lunds universitets profilområden,Gastroenterology,Lund University Research Groups,LTH Profile Area: Photon Science and Technology,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,Skåne University Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)medf-ksj
7001 a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)kir-boh
7001 a Almer, Svenu Karolinska Institutet,Karolinska Univ Hosp, Sweden,Karolinska University Hospital4 aut
7001 a Halfvarson, Jonasu Örebro University Hospital,Orebro Univ Hosp, Sweden4 aut
7001 a Miehlke, Stephanu University Medical Center Hamburg-Eppendorf,Univ Hosp Eppendorf, Germany4 aut
7001 a Madisch, Ahmedu CRH Clin Siloah, Germany4 aut
7001 a Lieb, Wolfgangu University of Kiel,Christian Albrechts Univ Kiel, Germany4 aut
7001 a Kupčinskas, Juozasu Lithuanian University of Health Sciences,Lithuanian Univ Hlth Sci, Lithuania4 aut
7001 a Weersma, Rinse K.u University Medical Center Groningen,Univ Groningen, Netherlands; Univ Med Ctr Groningen, Netherlands4 aut
7001 a Bujanda, Luisu CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd),Hospital Universitario Donostia,Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain; Donostia University Hospital, Spain4 aut
7001 a Julià, Antoniou Vall d'Hebron University Hospital,Vall Hebron Res Inst, Spain4 aut
7001 a Marsal, Sarau Vall d'Hebron University Hospital,Vall Hebron Res Inst, Spain4 aut
7001 a Esteve, Mariau Mutua De Terrassa Hospital,CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd),Hosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain4 aut
7001 a Guagnozzi, Danilau Vall d'Hebron University Hospital,CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd),Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain; Vall Hebron Univ Hosp, Spain4 aut
7001 a Fernández-Bañares, Fernandou Mutua De Terrassa Hospital,CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd),Hosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain4 aut
7001 a Ferrer, Carmenu Mutua De Terrassa Hospital,Hosp Univ Mutua Terrassa, Spain4 aut
7001 a Peter, Ingau Icahn School of Medicine at Mount Sinai,Icahn Sch Med Mt Sinai, NY USA4 aut
7001 a Ludvigsson, Jonas F.u Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden4 aut
7001 a Pardi, Darrellu Mayo Clinic Minnesota,Mayo Clin, MN USA4 aut
7001 a Verhaegh, Basu Maastricht University,Maastricht Univ, Netherlands4 aut
7001 a Jonkers, Daisyu Maastricht University,Maastricht Univ, Netherlands4 aut
7001 a Pierik, Mariekeu Maastricht University,Maastricht Univ, Netherlands4 aut
7001 a Münch, Andreasu Linköpings universitet,Linköping University,Center For Cooperative Research In Biosciences (CIC bioGUNE),Avdelningen för molekylär medicin och virologi,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)andsa76
7001 a Franke, Andreu University of Kiel,Univ Kiel, Germany4 aut
7001 a Bresso, Francescau Karolinska Institutet,Karolinska Univ Hosp, Sweden,Karolinska University Hospital4 aut
7001 a Khalili, Hamedu Massachusetts General Hospital,Massachusetts Institute of Technology,Massachusetts Gen Hosp, MA USA; Broad Inst Massachusetts Inst Technol & Harvard, MA USA4 aut
7001 a Colombel, Jean Fredericu Icahn School of Medicine at Mount Sinai,Icahn Sch Med Mt Sinai, NY USA4 aut
7001 a D’Amato, Maurou Karolinska Institute,Basque Foundation for Science,Center For Cooperative Research In Biosciences (CIC bioGUNE),Karolinska Inst, Sweden; CIC bioGUNE BRTA, Spain; Basque Fdn Sci, Spain; LUM Univ, Italy4 aut
7001 a Presser, Lance4 aut
7001 a Teirlinck, Anne4 aut
7001 a Knol, Mirjam4 aut
7001 a Piqueras, Martau Consorci Sanitari de Terrassa4 aut
7001 a Busquets, Davidu Hospital Universitari de Girona Dr. Josep Trueta4 aut
7001 a Iglesias, Evau Hospital Universitario Reina Sofia4 aut
7001 a Lucendo, Alfredo J.u CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd)4 aut
7102 a Karolinska Instituteb Monash University4 org
7102 a MC-Europe GETECCU GWAS group
7730 t Journal of Crohn's and Colitisd : OXFORD UNIV PRESSg 18:3, s. 349-359q 18:3<349-359x 1873-9946x 1876-4479
8564 u http://dx.doi.org/10.1093/ecco-jcc/jjad165y FULLTEXT
8564 8u https://lup.lub.lu.se/record/8ee4455e-30c9-4ed5-b985-fd248c7f5cbb
8564 8u https://doi.org/10.1093/ecco-jcc/jjad165
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:153972347
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198977

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