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Dynamics of a Staph...
Dynamics of a Staphylococcus aureus infective endocarditis simulation model
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- Schwartz, Franziska A. (författare)
- Copenhagen University Hospital
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- Nielsen, Luna (författare)
- Copenhagen University Hospital
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- Andersen, Jessica Struve (författare)
- Copenhagen University Hospital
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- Bock, Magnus (författare)
- Copenhagen University Hospital
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- Christophersen, Lars (författare)
- Copenhagen University Hospital
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- Sunnerhagen, Torgny (författare)
- Lund University,Lunds universitet,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Translational infection medicine,Lund University Research Groups,Copenhagen University Hospital,Region Skåne
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- Lerche, Christian Johann (författare)
- Copenhagen University Hospital
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- Bay, Lene (författare)
- University of Copenhagen
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- Bundgaard, Henning (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Høiby, Niels (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Moser, Claus (författare)
- Copenhagen University Hospital,University of Copenhagen
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(creator_code:org_t)
- 2022-05-27
- 2022
- Engelska.
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Ingår i: APMIS. - : Wiley. - 0903-4641 .- 1600-0463. ; 130:8, s. 515-523
- Relaterad länk:
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Infective endocarditis (IE) is a serious infection of the inner surface of heart, resulting from minor lesions in the endocardium. The damage induces a healing reaction, which leads to recruitment of fibrin and immune cells. This sterile healing vegetation can be colonized during temporary bacteremia, inducing IE. We have previously established a novel in vitro IE model using a simulated IE vegetation (IEV) model produced from whole venous blood, on which we achieved stable bacterial colonization after 24h. The bacteria were organized in biofilm aggregates and displayed increased tolerance towards antibiotics. In this current study, we aimed at further characterizing the time course of biofilm formation and the impact on antibiotic tolerance development. We found that a S. aureus reference strain, as well as three clinical IE isolates formed biofilms on the IEV after 6h. When treatment was initiated immediately after infection, the antibiotic effect was significantly higher than when treatment was started after the biofilm was allowed to mature. We could follow the biofilm development microscopically by visualizing growing bacterial aggregates on the IEV. The findings indicate that mature, antibiotic-tolerant biofilms can be formed in our model already after 6h, accelerating the screening for optimal treatment strategies for IE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Schwartz, Franzi ...
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Nielsen, Luna
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Andersen, Jessic ...
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Bock, Magnus
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Christophersen, ...
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Sunnerhagen, Tor ...
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Lerche, Christia ...
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Bay, Lene
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Bundgaard, Henni ...
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Høiby, Niels
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Moser, Claus
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