Sökning: onr:"swepub:oai:lup.lub.lu.se:8f1ca54b-0068-4f27-be30-8c56998048b3" >
Combination of cGMP...
Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration
-
- Vighi, Eleonora (författare)
- University of Modena and Reggio Emilia
-
- Trifunovic, Dragana (författare)
- University of Tübingen
-
- Veiga-Crespo, Patricia (författare)
- Lund University,Lunds universitet,Retinal degeneration: Molekylär patologi,Forskargrupper vid Lunds universitet,Retinal degeneration: Molecular Pathology,Lund University Research Groups
-
visa fler...
-
- Rentsch, Andreas (författare)
- BIOLOG Life Science Institute
-
- Hoffmann, Dorit (författare)
- University of Modena and Reggio Emilia
-
- Sahaboglu, Ayse (författare)
- University of Tübingen
-
- Strasser, Torsten (författare)
- University of Tübingen
-
- Kulkarni, Manoj (författare)
- University of Tübingen
-
- Bertolotti, Evelina (författare)
- University of Modena and Reggio Emilia
-
- Van Den Heuvel, Angelique (författare)
- to-BBB technologies BV
-
- Peters, Tobias (författare)
- University of Tübingen
-
- Reijerkerk, Arie (författare)
- to-BBB technologies BV
-
- Euler, Thomas (författare)
- University of Tübingen
-
- Ueffing, Marius (författare)
- University of Tübingen
-
- Schwede, Frank (författare)
- BIOLOG Life Science Institute
-
- Genieser, Hans Gottfried (författare)
- BIOLOG Life Science Institute
-
- Gaillard, Pieter (författare)
- to-BBB technologies BV
-
- Marigo, Valeria (författare)
- University of Modena and Reggio Emilia
-
- Ekström, Per (författare)
- Lund University,Lunds universitet,Retinal degeneration: Molekylär patologi,Forskargrupper vid Lunds universitet,Retinal degeneration: Molecular Pathology,Lund University Research Groups
-
- Paquet-Durand, François (författare)
- University of Tübingen
-
visa färre...
-
(creator_code:org_t)
- 2018-03-12
- 2018
- Engelska.
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 115:13, s. 2997-3006
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://www.pnas.org...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Inherited retinal degeneration (RD) is a devastating and currently untreatable neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The vast genetic heterogeneity of RD, the lack of “druggable” targets, and the access-limiting blood–retinal barrier (BRB) present major hurdles toward effective therapy development. Here, we address these challenges (i) by targeting cGMP (cyclic guanosine- 3′,5′-monophosphate) signaling, a disease driver common to different types of RD, and (ii) by combining inhibitory cGMP analogs with a nanosized liposomal drug delivery system designed to facilitate transport across the BRB. Based on a screen of several cGMP analogs we identified an inhibitory cGMP analog that interferes with activation of photoreceptor cell death pathways. Moreover, we found liposomal encapsulation of the analog to achieve efficient drug targeting to the neuroretina. This pharmacological treatment markedly preserved in vivo retinal function and counteracted photoreceptor degeneration in three different in vivo RD models. Taken together, we show that a defined class of compounds for RD treatment in combination with an innovative drug delivery method may enable a single type of treatment to address genetically divergent RD-type diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Apoptosis
- Calpain
- CNG channel
- In vivo imaging
- PKG
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Vighi, Eleonora
-
Trifunovic, Drag ...
-
Veiga-Crespo, Pa ...
-
Rentsch, Andreas
-
Hoffmann, Dorit
-
Sahaboglu, Ayse
-
visa fler...
-
Strasser, Torste ...
-
Kulkarni, Manoj
-
Bertolotti, Evel ...
-
Van Den Heuvel, ...
-
Peters, Tobias
-
Reijerkerk, Arie
-
Euler, Thomas
-
Ueffing, Marius
-
Schwede, Frank
-
Genieser, Hans G ...
-
Gaillard, Pieter
-
Marigo, Valeria
-
Ekström, Per
-
Paquet-Durand, F ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Oftalmologi
- Artiklar i publikationen
-
Proceedings of t ...
-
Proceedings of t ...
- Av lärosätet
-
Lunds universitet