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Hereditary colorect...
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Henriksson, IsabelleLund University
(författare)
Hereditary colorectal cancer diagnostics in southern Sweden : retrospective evaluation and future considerations with emphasis on Lynch syndrome
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2018-09-24
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Springer Science and Business Media LLC,2019
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:8f5229a5-f723-4b6f-bc6f-30e67bc8a7b3
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https://lup.lub.lu.se/record/8f5229a5-f723-4b6f-bc6f-30e67bc8a7b3URI
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https://doi.org/10.1007/s12687-018-0385-1DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Overlapping phenotypes between different hereditary colorectal cancer (CRC) syndromes together with a growing demand for cancer genetic testing and improved sequencing technology call for adjusted patient selection and adapted diagnostic routines. Here we present a retrospective evaluation of family history of cancer, laboratory diagnostic procedure, and outcome for 372 patients tested for Lynch syndrome (LS), i.e., the single most common hereditary cause of CRC. Based on number of affected family members and age at cancer diagnosis in families with genetically confirmed LS, we developed local patient selection criteria for a simplified one-step gene panel mutation screening strategy targeting also less common Mendelian CRC syndromes. Pros and cons of this strategy are discussed.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Henriksson, KarinLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-khe
(författare)
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Ehrencrona, HansLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-hen
(författare)
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Gebre-Medhin, SamuelLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)mphy-sgm
(författare)
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Lund UniversityBröstcancer-genetik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Community Genetics: Springer Science and Business Media LLC10:2, s. 259-2661868-310X1868-6001
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